keywords BLOOD-BRAIN-BARRIER BONE-MARROW-TRANSPLANTATION Biotechnology & Applied Microbiology CENTRAL-NERVOUS-SYSTEM CHIMERIC MONOCLONAL-ANTIBODY COAGULATION-FACTOR-IX Cell & Tissue Engineering Cell Biology ENZYME-REPLACEMENT THERAPY Engineering Engineering, Biomedical HUMAN BETA-GLUCURONIDASE HUMAN-FACTOR-IX Life Sciences & Biomedicine MICROENCAPSULATED ENGINEERED CELLS MUCOPOLYSACCHARIDOSIS TYPE-VII Materials Science Materials Science, Biomaterials Science & Technology Technology