New anthropometry-based age- and sex-specific reference values for urinary 24-hour creatinine excretion based on the adult Swiss population Academic Article uri icon

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abstract

  • BACKGROUND: Urinary creatinine excretion is used as a marker of completeness of timed urine collections, which are a keystone of several metabolic evaluations in clinical investigations and epidemiological surveys. METHODS: We used data from two independent Swiss cross-sectional population-based studies with standardised 24-hour urinary collection and measured anthropometric variables. Only data from adults of European descent, with estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m2 and reported completeness of the urinary collection were retained. A linear regression model was developed to predict centiles of the 24-hour urinary creatinine excretion in 1,137 participants from the Swiss Survey on Salt and validated in 994 participants from the Swiss Kidney Project on Genes in Hypertension. RESULTS: The mean urinary creatinine excretion was 193 ± 41 μmol/kg/24 hours in men and 151 ± 38 μmol/kg/24 hours in women in the Swiss Survey on Salt. The values were inversely correlated with age and body mass index (BMI). CONCLUSIONS: We propose a validated prediction equation for 24-hour urinary creatinine excretion in the general European population, based on readily available variables such as age, sex and BMI, and a few derived normograms to ease its clinical application. This should help healthcare providers to interpret the completeness of a 24-hour urine collection in daily clinical practice and in epidemiological population studies.

authors

  • Conen, David
  • Forni Ogna, Valentina
  • Ogna, Adam
  • Vuistiner, Philippe
  • Pruijm, Menno
  • Ponte, Belen
  • Ackermann, Daniel
  • Gabutti, Luca
  • Vakilzadeh, Nima
  • Mohaupt, Markus
  • Martin, Pierre-Yves
  • Guessous, Idris
  • Péchère-Bertschi, Antoinette
  • Paccaud, Fred
  • Bochud, Murielle
  • Burnier, Michel

publication date

  • December 2015