Journal article
Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals
Abstract
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously …
Authors
Dastani Z; Hivert M-F; Timpson N; Perry JRB; Yuan X; Scott RA; Henneman P; Heid IM; Kizer JR; Lyytikäinen L-P
Journal
PLOS Genetics, Vol. 8, No. 3,
Publisher
Public Library of Science (PLoS)
Publication Date
2012
DOI
10.1371/journal.pgen.1002607
ISSN
1553-7390
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdiponectinBlack or African AmericanAsian PeopleCholesterol, HDLDiabetes Mellitus, Type 2FemaleGene ExpressionGenetic Predisposition to DiseaseGenome-Wide Association StudyGlucose Tolerance TestHumansInsulin ResistanceMaleMetabolic Networks and PathwaysPolymorphism, Single NucleotideWaist-Hip RatioWhite People