[Arg8]vasopressin-induced contractions of rabbit urinary bladder smooth muscle

The effects of a number of neurohypophyseal hormones and analogues on the contractility of rabbit urinary bladder smooth muscle in vitro were examined. The order of potency was [Arg8]vasopressin = [Lys8]vasotocin greater than [Lys8]vasopressin greater than [Arg8]vasotocin much greater than [deamino1,D-Arg8]vasopressin greater than oxytocin much greater than pressinoic acid. The maximum tension induced by [Arg8]vasopressin was 4.4 N . cm-2 and …