Journal article
Colonic dysmotility in postsurgical patients with Hirschsprung's disease. Potential significance of abnormalities in the interstitial cells of Cajal and the enteric nervous system
Abstract
PURPOSE: Normal gut muscular function depends on the coordinated activity of both the enteric nervous system (ENS) and the interstitial cells of Cajal (ICC). Hirschsprung's disease (HD) has long been considered a purely neuronal deficit but recent data point to abnormalities in ICC in the proximal ganglionated HD colon. We examined the labeling of ICC and neuronal cells in the proximal ganglionated colon in patients with HD to determine whether …
Authors
Bettolli M; De Carli C; Jolin-Dahel K; Bailey K; Khan HF; Sweeney B; Krantis A; Staines WA; Rubin S
Journal
Journal of Pediatric Surgery, Vol. 43, No. 8, pp. 1433–1438
Publisher
Elsevier
Publication Date
August 2008
DOI
10.1016/j.jpedsurg.2007.10.067
ISSN
0022-3468
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Biopsy, NeedleCase-Control StudiesConstipationDigestive System AbnormalitiesDigestive System Surgical ProceduresEnteric Nervous SystemFemaleFollow-Up StudiesGastrointestinal MotilityHirschsprung DiseaseHumansImmunohistochemistryInfantInfant, NewbornMaleMuscle, SmoothMyenteric PlexusNeuronal PlasticityProbabilityReference ValuesRisk AssessmentTissue Culture TechniquesTreatment Outcome