Chapter
In Vitro Assays for Screening Small Molecules
Abstract
Traditionally anti-cancer therapeutics have been designed to target rapidly proliferating cells causing DNA damage and inducing apoptosis. However, with the development of the cancer stem cell (CSC) hypothesis, it has been postulated that a rare, slow dividing tumor cell population is able to escape therapy and contribute to tumor relapse and metastasis. The advances in characterization of CSCs across multiple cancer subtypes have allowed for …
Authors
Adile AA; Bakhshinyan D; Venugopal C; Singh SK
Book title
Brain Tumor Stem Cells
Series
Methods in Molecular Biology
Volume
1869
Pagination
pp. 189-196
Publisher
Springer Nature
Publication Date
2019
DOI
10.1007/978-1-4939-8805-1_16