Journal article
Metabolic Syndrome and Acute Hyperglycemia Are Associated With Endoplasmic Reticulum Stress in Human Mononuclear Cells
Abstract
Endoplasmic reticulum (ER) stress and the activation of the unfolded protein response (UPR) have been implicated in a number of complications associated with diabetes mellitus including micro- and macrovascular dysfunction. In this study we examine ER stress levels in blood cells isolated from human subjects with metabolic syndrome and in healthy controls. Total RNA and protein were isolated from leukocytes and the levels of specific ER stress …
Authors
Sage AT; Holtby‐Ottenhof S; Shi Y; Damjanovic S; Sharma AM; Werstuck GH
Journal
Obesity, Vol. 20, No. 4, pp. 748–755
Publisher
Wiley
Publication Date
April 2012
DOI
10.1038/oby.2011.144
ISSN
1930-7381
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Acute DiseaseAdultCalreticulinCase-Control StudiesDNA-Binding ProteinsEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressFemaleGlucose Tolerance TestHeat-Shock ProteinsHumansHyperglycemiaImmunoblottingInterleukin-1Interleukin-6Interleukin-8MaleMetabolic SyndromeMonocytesRNA, MessengerReal-Time Polymerase Chain ReactionRegulatory Factor X Transcription FactorsSignal TransductionTranscription Factor CHOPTranscription FactorsUnfolded Protein ResponseX-Box Binding Protein 1