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Metabolic Syndrome and Acute Hyperglycemia Are...
Journal article

Metabolic Syndrome and Acute Hyperglycemia Are Associated With Endoplasmic Reticulum Stress in Human Mononuclear Cells

Abstract

Endoplasmic reticulum (ER) stress and the activation of the unfolded protein response (UPR) have been implicated in a number of complications associated with diabetes mellitus including micro- and macrovascular dysfunction. In this study we examine ER stress levels in blood cells isolated from human subjects with metabolic syndrome and in healthy controls. Total RNA and protein were isolated from leukocytes and the levels of specific ER stress …

Authors

Sage AT; Holtby‐Ottenhof S; Shi Y; Damjanovic S; Sharma AM; Werstuck GH

Journal

Obesity, Vol. 20, No. 4, pp. 748–755

Publisher

Wiley

Publication Date

April 2012

DOI

10.1038/oby.2011.144

ISSN

1930-7381