Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation Academic Article uri icon

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abstract

  • OBJECTIVE: To evaluate the relationship between use of fertility medication (i.e., selective estrogen receptor [ER] modulator, gonadotropin, or other) or infertility treatment (i.e., IVF or IUI) and the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation. DESIGN: A matched case-control study of 941 pairs of BRCA1 or BRCA2 mutation carriers with and without a diagnosis of ovarian cancer. SETTING: Genetic clinics. PATIENT(S): Detailed information regarding treatment of infertility was collected from a routinely administered questionnaire. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Conditional logistic regression was used to estimate odds ratios and 95% confidence intervals associated with fertility treatment. RESULT(S): There was no significant relationship between the use of any fertility medication or IVF treatment (odds ratio, 0.66; 95% confidence interval 0.18-2.33) and the subsequent risk of ovarian cancer. CONCLUSION(S): Our findings suggest that treatment for infertility does not significantly increase the risk of ovarian cancer among women with a BRCA mutation.

authors

  • Gronwald, Jacek
  • Glass, Karen
  • Rosen, Barry
  • Karlan, Beth
  • Tung, Nadine
  • Neuhausen, Susan L
  • Moller, Pal
  • Ainsworth, Peter
  • Sun, Ping
  • Narod, Steven A
  • Lubinski, Jan
  • Kotsopoulos, Joanne
  • Lynch, Henry T
  • Cybulski, Cezary
  • Kim-Sing, Charmaine
  • Friedman, Susan
  • Senter, Leigha
  • Weitzel, Jeffrey
  • Singer, Christian
  • Eng, Charis
  • Mitchell, Gillian
  • Huzarski, Tomasz
  • McCuaig, Jeanna
  • Eisen, Andrea
  • Gilchrist, Dawna
  • Blum, Joanne L
  • Zakalik, Dana
  • Pal, Tuya
  • Daly, Mary
  • Weber, Barbara
  • Snyder, Carrie
  • Fallen, Taya
  • Chudley, Albert
  • Lunn, John
  • Donenberg, Talia
  • Kurz, Raluca N
  • Saal, Howard
  • Garber, Judy
  • Rennert, Gad
  • Sweet, Kevin
  • Rappaport, Christine
  • Lemire, Edmond
  • Stoppa-Lyonnet, Dominique
  • Olopade, Olufunmilayo I
  • Merajver, Sofia
  • Bordeleau, Louise
  • Cullinane, Carey A
  • Friedman, Eitan
  • McKinnon, Wendy
  • Wood, Marie
  • Rayson, Daniel
  • Meschino, Wendy
  • Costalas, Josephine Wagner
  • Reilly, Robert E
  • Vadaparampil, Susan
  • Offit, Kenneth
  • Kauff, Noah
  • Euhus, David
  • Kwong, Ava
  • Isaacs, Claudine
  • Couch, Fergus
  • Manoukian, Siranoush
  • Byrski, Tomasz
  • Elser, Christine
  • Panchal, Seema
  • Armel, Susan
  • Demsky, Rochelle
  • Nanda, Sonia
  • Metcalfe, Kelly
  • Poll, Aletta
  • Foulkes, William D
  • Robidoux, Andre
  • Warner, Ellen
  • Maehle, Lovise
  • Evans, Gareth
  • Pasini, Barbara
  • Ginsburg, Ophira
  • Cohen, Stephanie
  • Jakubowska, Anna
  • Little, Janice

publication date

  • March 2016

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