A complex dynamic model for cancer growth and metastasis

Unregulated cancer cell proliferation requires nutrients such as glucose and iron. Iron is a requisite cofactor for activating ribonucleotide reductase, an enzyme that converts ribonucleotide triphosphates into dNTPs and thus, constitutes a vital component in DNA synthesis. The demonstration that cancer cells arrest and become apoptotic in the absence of iron has made this nutrient an attractive chemotherapeutic candidate. Herein, we elaborate …