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Pain Perception in Acute Model Mice of Parkinson's...

Journal article

Pain Perception in Acute Model Mice of Parkinson's Disease Induced by 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)

Abstract

Background Pain is the most prominent non-motor symptom observed in patients with Parkinson's disease (PD). However, the mechanisms underlying the generation of pain in PD have not been well studied. We used a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD to analyze the relationship between pain sensory abnormalities and the degeneration of dopaminergic neurons. Results The latency to fall off the rotarod and the …

Authors

Park J; Lim C-S; Seo H; Park C-A; Zhuo M; Kaang B-K; Lee K

Journal

Molecular Pain, Vol. 11, ,

Publisher

SAGE Publications

Publication Date

January 1, 2015

DOI

10.1186/s12990-015-0026-1

ISSN

1744-8069

Associated Experts

Derek Chu

Assistant Professor, Faculty of Health Sciences

Labels

Medical Subject Headings (MeSH)

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Animals Astrocytes Corpus Striatum Disease Models, Animal Dopamine Male Mice Mice, Inbred C57BL Microglia Motor Activity Neurons Pain Perception Parkinson Disease

Fields of Research (FoR)

3209 Neurosciences

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