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Improved adjuvanting of seasonal influenza...
Journal article

Improved adjuvanting of seasonal influenza vaccines: Preclinical studies of MVA‐NP+M1 coadministration with inactivated influenza vaccine

Abstract

Licensed seasonal influenza vaccines induce antibody (Ab) responses against influenza hemagglutinin (HA) that are limited in their ability to protect against different strains of influenza. Cytotoxic T lymphocytes recognizing the conserved internal nucleoprotein (NP) and matrix protein (M1) are capable of mediating a cross-subtype immune response against influenza. Modified vaccinia Ankara (MVA) virus encoding NP and M1 (MVA-NP+M1) is designed …

Authors

Mullarkey CE; Boyd A; van Laarhoven A; Lefevre EA; Carr BV; Baratelli M; Molesti E; Temperton NJ; Butter C; Charleston B

Journal

European Journal of Immunology, Vol. 43, No. 7, pp. 1940–1952

Publisher

Wiley

Publication Date

July 2013

DOI

10.1002/eji.201242922

ISSN

0014-2980