Journal article
Measles Vaccines Designed for Enhanced CD8+ T Cell Activation
Abstract
Priming and activation of CD8+ T cell responses is crucial to achieve anti-viral and anti-tumor immunity. Live attenuated measles vaccine strains have been used successfully for immunization for decades and are currently investigated in trials of oncolytic virotherapy. The available reverse genetics systems allow for insertion of additional genes, including heterologous antigens. Here, we designed recombinant measles vaccine vectors for priming …
Authors
Busch E; Kubon KD; Mayer JKM; Pidelaserra-Martí G; Albert J; Hoyler B; Heidbuechel JPW; Stephenson KB; Lichty BD; Osen W
Journal
Viruses, Vol. 12, No. 2,
Publisher
MDPI
DOI
10.3390/v12020242
ISSN
1999-4915