Conference
Understanding the Factor Va Cofactor Effect within Prothrombinase.
Abstract
Abstract
Activation of human prothrombin (Pro) occurs following two cleavages by membrane-bound factor Xa (fXa) (Arg271 followed by Arg320, generating prethrombin 2 as intermediate). Binding of factor Va (fVa) to fXa on a membrane surface in the presence of divalent metal ions results in the formation of prothrombinase (IIase). It has been established that IIase is a 1:1 stochiometric complex between fVa and fXa on a lipid …
Authors
Kalafatis M; Bukys MA; Hirbawi J; Kim PY; Barhoover MA; Nesheim ME
Volume
110
Publisher
American Society of Hematology
Publication Date
November 16, 2007
DOI
10.1182/blood.v110.11.2700.2700
Conference proceedings
Blood
Issue
11
ISSN
0006-4971