Journal article
An evaluation of the anti‐hyperalgesic effects of cannabidiolic acid‐methyl ester in a preclinical model of peripheral neuropathic pain
Abstract
BACKGROUND AND PURPOSE: Chronic neuropathic pain (NEP) is associated with growing therapeutic cannabis use. To promote quality of life without psychotropic effects, cannabinoids other than Δ9-tetrahydrocannabidiol, including cannabidiol and its precursor cannabidiolic acid (CBDA), are being evaluated. Due to its instability, CBDA has been understudied, particularly as an anti-nociceptive agent. Adding a methyl ester group (CBDA-ME) …
Authors
Zhu YF; Linher‐Melville K; Niazmand MJ; Sharma M; Shahid A; Zhu KL; Parzei N; Sidhu J; Haj C; Mechoulam R
Journal
British Journal of Pharmacology, Vol. 177, No. 12, pp. 2712–2725
Publisher
Wiley
Publication Date
June 2020
DOI
10.1111/bph.14997
ISSN
0007-1188