Journal article
Reverse translation of major depressive disorder symptoms: A framework for the behavioural phenotyping of putative biomarkers
Abstract
BACKGROUND: Reverse translating putative biomarkers of depression from patients to animals is complex because Major Depressive Disorder (MDD) is a highly heterogenous condition. This review proposes an approach to reverse translation based on relating relevant bio-behavioural functions in laboratory rodents to MDD symptoms.
METHODS: This systematic review outlines symptom clusters assessed by psychometric tests of MDD and antidepressant …
Authors
Daniels S; Horman T; Lapointe T; Melanson B; Storace A; Kennedy SH; Frey BN; Rizvi SJ; Hassel S; Mueller DJ
Journal
Journal of Affective Disorders, Vol. 263, , pp. 353–366
Publisher
Elsevier
Publication Date
February 2020
DOI
10.1016/j.jad.2019.11.108
ISSN
0165-0327