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Large-Scale Gene-Centric Analysis Identifies Novel...
Journal article

Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease

Abstract

Coronary artery disease (CAD) has a significant genetic contribution that is incompletely characterized. To complement genome-wide association (GWA) studies, we conducted a large and systematic candidate gene study of CAD susceptibility, including analysis of many uncommon and functional variants. We examined 49,094 genetic variants in ∼2,100 genes of cardiovascular relevance, using a customised gene array in 15,596 CAD cases and 34,992 …

Authors

Consortium TIKC

Journal

PLOS Genetics, Vol. 7, No. 9,

Publisher

Public Library of Science (PLoS)

Publication Date

September 2011

DOI

10.1371/journal.pgen.1002260

ISSN

1553-7390