Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial Academic Article uri icon

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abstract

  • BACKGROUND: Results of small trials indicate that fluoxetine might improve functional outcomes after stroke. The FOCUS trial aimed to provide a precise estimate of these effects. METHODS: FOCUS was a pragmatic, multicentre, parallel group, double-blind, randomised, placebo-controlled trial done at 103 hospitals in the UK. Patients were eligible if they were aged 18 years or older, had a clinical stroke diagnosis, were enrolled and randomly assigned between 2 days and 15 days after onset, and had focal neurological deficits. Patients were randomly allocated fluoxetine 20 mg or matching placebo orally once daily for 6 months via a web-based system by use of a minimisation algorithm. The primary outcome was functional status, measured with the modified Rankin Scale (mRS), at 6 months. Patients, carers, health-care staff, and the trial team were masked to treatment allocation. Functional status was assessed at 6 months and 12 months after randomisation. Patients were analysed according to their treatment allocation. This trial is registered with the ISRCTN registry, number ISRCTN83290762. FINDINGS: Between Sept 10, 2012, and March 31, 2017, 3127 patients were recruited. 1564 patients were allocated fluoxetine and 1563 allocated placebo. mRS data at 6 months were available for 1553 (99·3%) patients in each treatment group. The distribution across mRS categories at 6 months was similar in the fluoxetine and placebo groups (common odds ratio adjusted for minimisation variables 0·951 [95% CI 0·839-1·079]; p=0·439). Patients allocated fluoxetine were less likely than those allocated placebo to develop new depression by 6 months (210 [13·43%] patients vs 269 [17·21%]; difference 3·78% [95% CI 1·26-6·30]; p=0·0033), but they had more bone fractures (45 [2·88%] vs 23 [1·47%]; difference 1·41% [95% CI 0·38-2·43]; p=0·0070). There were no significant differences in any other event at 6 or 12 months. INTERPRETATION: Fluoxetine 20 mg given daily for 6 months after acute stroke does not seem to improve functional outcomes. Although the treatment reduced the occurrence of depression, it increased the frequency of bone fractures. These results do not support the routine use of fluoxetine either for the prevention of post-stroke depression or to promote recovery of function. FUNDING: UK Stroke Association and NIHR Health Technology Assessment Programme.

authors

  • Dennis, Martin
  • Mead, Gillian
  • Forbes, John
  • Graham, Catriona
  • Hackett, Maree
  • Hankey, Graeme J
  • House, Allan
  • Lewis, Stephanie
  • Lundström, Erik
  • Sandercock, Peter
  • Innes, Karen
  • Williams, Carol
  • Drever, Jonathan
  • Mcgrath, Aileen
  • Deary, Ann
  • Fraser, Ruth
  • Anderson, Rosemary
  • Walker, Pauli
  • Perry, David
  • Mcgill, Connor
  • Buchanan, David
  • Chun, Yvonne
  • Dinsmore, Lynn
  • Maschauer, Emma
  • Barugh, Amanda
  • Mikhail, Shadia
  • Blair, Gordon
  • Hoeritzauer, Ingrid
  • Scott, Maggie
  • Fraser, Greig
  • Lawrence, Katherine
  • Shaw, Alison
  • Williamson, Judith
  • Burgess, David
  • Macleod, Malcolm
  • Morales, Dan
  • Sullivan, Frank
  • Brady, Marian
  • French, Ray
  • Van Wijck, Frederike
  • Watkins, Caroline
  • Proudfoot, Fiona
  • Skwarski, Joanna
  • Mcgowan, Diane
  • Murphy, Rachael
  • Burgess, Seona
  • Rutherford, William
  • Mccormick, Katrina
  • Buchan, Ruaridh
  • Macraild, Allan
  • Paulton, Ruth
  • Fazal, Adnan
  • Taylor, Pat
  • Parakramawansha, Ruwan
  • Hunter, Neil
  • Perry, Jack
  • Bamford, John
  • Waugh, Dean
  • Veraque, Emelda
  • Bedford, Caroline
  • Kambafwile, Mary
  • Idrovo, Luis
  • Makawa, Linetty
  • Smalley, Paula
  • Randall, Marc
  • Thirugnana-Chandran, Tharani
  • Hassan, Ahamad
  • Vowden, Richard
  • Jackson, Joanne
  • Bhalla, Ajay
  • Rudd, Anthony
  • Tam, Chi Kai
  • Birns, Jonathan
  • Gibbs, Charlotte
  • Lee Carbon, Leonie
  • Cattermole, Elizabeth
  • Marks, Katherine
  • Cape, Angela
  • Hurley, Lisa
  • Kullane, Sagal
  • Smyth, Nigel
  • Eglinton, Charlotte
  • Wilson, Jennifer
  • Giallombardo, Elio
  • Frith, Angela
  • Reidy, Paul
  • Pitt, Matthew
  • Sykes, Lucy
  • Dellafera, Deborah
  • Croome, Victoria
  • Kerwood, Lauriane
  • Hancevic, Mirea
  • Narh, Christina
  • Merritt, Carley
  • Duffy, John
  • Cooke, Duncan
  • Willson, Juliet
  • Ali, Ali
  • Naqvi, Aaizza
  • Kamara, Christine
  • Bowler, Helen
  • Bell, Simon
  • Jackson, Tracy
  • Harkness, Kirsty
  • Stocks, Kathy
  • Duty, Suzanna
  • Doyle, Clare
  • Dunn, Geoffrey
  • Endean, Keith
  • Claydon, Fiona
  • Richards, Emma
  • Howe, Jo
  • Lindert, Ralf
  • Majid, Arshad
  • Dakin, Katy
  • Maatouk, Ahmad
  • Barron, Luke
  • Meegada, Madana
  • Rana, Pratap
  • Nair, Anand
  • Brighouse-Johnson, Christine
  • Greig, Jill
  • Kyu, Myint
  • Prasad, Sanjeev
  • Robinson, Matthew
  • Alam, Irfan
  • Mclean, Belinda
  • Greenhalgh, Lindsay
  • Ahmed, Zenab
  • Roffe, Christine
  • Brammer, Susan
  • Beardmore, Carole
  • Finney, Kay
  • Barry, Adrian
  • Hollinshead, Paul
  • Grocott, Jeanette
  • Maguire, Holly
  • Natarajan, Indira
  • Chembala, Jayan
  • Sanyal, Ranjan
  • Lijko, Sue
  • Abano, Nenette
  • Remegoso, Alda
  • Ferdinand, Phillip
  • Stevens, Stephanie
  • Varquez, Resti
  • Causley, Chelsea
  • Butler, Adrian
  • Whitmore, Philip
  • Stephen, Caroline
  • Carpio, Racquel
  • Hiden, Joanne
  • Muddegowda, Girish
  • Denic, Hayley
  • Sword, Jane
  • Curwen, Ross
  • James, Martin
  • Mudd, Paul
  • Hall, Fiona
  • Cageao, Julie
  • Keenan, Samantha
  • Roughan, Caroline
  • Kingwell, Hayley
  • Hemsley, Anthony
  • Lohan, Christoph
  • Davenport, Sue
  • Bowring, Angela
  • Chapter, Tamika
  • Hough, Max
  • Strain, David
  • Gupwell, Karin
  • Miller, Keniesha
  • Goff, Anita
  • Cusack, Ellie
  • Todd, Shirley
  • Partridge, Rebecca
  • Jennings, Georgiana
  • Thorpe, Kevin
  • Stephenson, Jacquelyn
  • Littlewood, Kelly
  • Barber, Mark
  • Brodie, Fiona
  • Marshall, Steven
  • Esson, Derek
  • Coburn, Irene
  • Mcinnes, Caroline
  • Ross, Fiona
  • Bowie, Emma
  • Barcroft, Heather
  • Withers, Victoria
  • Miller, Laura
  • Willcoxson, Paul
  • Donninson, Michelle
  • Evans, Richard
  • Daniel, Di
  • Coyle, John
  • Keeling, Michael
  • Wanklyn, Peter
  • Elliott, Mark
  • Wightman, John
  • Iveson, Elizabeth
  • Dyer, Natasha
  • Porteous, Anne-Marie
  • Haritakis, Monica
  • Ward, Mandy
  • Doughty, Lucy
  • Carr, Lisa
  • O Neill, Mark
  • Anazodo, Cosmas
  • Wood, Paul
  • Cottrell, Poppy
  • Donne, Cheryl
  • Rodriguez, Romina
  • Mir, Ruhail
  • Westmoreland, Jax
  • Bell, Judith
  • Emms, Christopher
  • Wright, Lorraine
  • Clark Brown, Pearl
  • Bamford, Elizabeth
  • Stanners, Andrew
  • Carpenter, Mike
  • Datta, Prabal
  • Davey, Richard
  • Needle, Ann
  • Eastwood, Marjorie Jane
  • Razik, Fathima Zeena
  • Ghouri, Imran
  • Bateman, Gavin
  • Archer, Judy
  • Balasubramanian, Venkatesh
  • Bowers, Richard
  • Ball, Julie
  • Benton, Louise
  • Jackson, Linda
  • Ellam, Julie
  • Norton, Kate
  • Guyler, Paul
  • Dowling, Terry
  • Tysoe, Sharon
  • Harman, Paula
  • Kundu, Ashish
  • Omodunbi, Ololade
  • Loganathan, Thayalini
  • Chandler, Stuart
  • Noor, Shanas
  • Siddiqui, Anwer
  • Siddiqui, Amber
  • Kunhunny, Swapna
  • Sinha, Devesh
  • Sheppard, Martin
  • Rashmi, Sindhu
  • France, Elena
  • Orath Prabakaran, Rajalakshmi
  • Wilson, Laura
  • Ropun, Amiirah
  • Kelavkar, Shyam
  • Ng, Kheng Xiong
  • Kamuriwo, Lucy
  • Shah, Sweni
  • Mangion, David
  • Constantin, Camen
  • De Michele Hock, Luigi
  • Hardwick, Anne
  • Borley, Jayne
  • Markova, Skarlet
  • Netherton, Kimberley
  • Lawrence, Tara
  • Fletcher, Jo
  • Spencer, Rebecca
  • Palmer, Helen
  • Cullen, Claire
  • Hamill, Dolores
  • Durairaj, Ramesh
  • Mellor, Zoe
  • Fluskey, Tanya
  • Wood, Diane
  • Keeling, Alison
  • Hankin, Victoria
  • Peters, Jennifer
  • Shackcloth, Daniela
  • Hlaing, Thant
  • Tangney, Rebecca
  • Ewing, Jordan
  • Harrison, Melanie
  • Stevenson, Sarah
  • Sutton, Victoria
  • Soliman, Mohamed
  • Hindle, Julia
  • Watson, Elizabeth
  • Hewitt, Claire
  • Borley, Jayne
  • Butler, Susie
  • Wahishi, Ibrahim
  • Arif, Sarwat
  • Fields, Amy
  • Sharma, Jagdish
  • Brown, Rose
  • Taylor, Caroline
  • Bell, Sarah
  • Leach, Simon
  • Patterson, Chris
  • Khan, Sophia
  • Wilson, Helen
  • Price, Joanne
  • Ramadan, Hawraman
  • Maguire, Stuart
  • Bellfield, Ruth
  • Hooley, Michaela
  • Hamid, Umair
  • Gaba, Waqar
  • Ghulam, Robina
  • Masters, Leslie
  • Quinn, Outi
  • Sekaran, Lakshmanan
  • Tate, Margaret
  • Mohammed, Niaz
  • Bharaj, Kiranjit
  • Justin, Frances
  • Pattni, Rajan
  • Alwis, Lanka
  • Sethuraman, Sakthivel
  • Robinson, Rianne
  • Eldridge, Lianne
  • Mintias, Susan
  • Chauhan, Meena
  • Tam, Chi-Kai
  • Palmones, Jeremias
  • Holmes, Clare
  • Guthrie, Lucy Belle
  • Osborn, Mairead
  • Ball, Lindsay
  • Caine, Sarah
  • Steele, Amy
  • Murphy, Peter
  • Devitt, Nikki
  • Leonard, Jayne
  • Patel, Ronak
  • Penwarden, Ian
  • Dodd, Emily
  • Holloway, Amy
  • Baker, Pauline
  • Clarke, Samantha
  • Williams, Sandra
  • Dow, Lindsey
  • Wynn-Williams, Roland
  • Kennedy, James
  • Teal, Rachel
  • Schulz, Ursula
  • Ford, Gary
  • Mathieson, Philip
  • Reckless, Ian
  • Deveciana, Ana
  • Mccann, Paige
  • Cluckie, Gillian
  • Howell, Geoffrey
  • Ayer, Jonathan
  • Moynihan, Barry
  • Ghatala, Rita
  • Clarke, Brian
  • Cloud, Geoffrey
  • Patel, Bhavini
  • Khan, Usman
  • Al-Samarrai, Nia
  • Trippier, Sarah
  • Chopra, Neha
  • Adedoyin, Temi
  • Watson, Fran
  • Jones, Val
  • Zhang, Liqun
  • Choy, Lillian
  • Williams, Rebecca
  • Clarke, Natasha
  • Blight, Adrian
  • Kennedy, Kate
  • Dainty, Alice
  • Selvarajah, Johann
  • Kalladka, Dheeraj
  • Cheripelli, Bharath
  • Smith, Wilma
  • Moreton, Fiona
  • Welch, Angela
  • Huang, Xuya
  • Douglas, Elizabeth
  • Lush, Audrey
  • Day, Nicola
  • El Tawil, Salwa
  • Montgomery, Karen
  • Hamilton, Helen
  • Ritchie, Doreen
  • Ramachandra, Sankaranarayanan
  • Mcleish, Kirsty
  • Thavanesan, Kamy
  • Loganathan, Sathyabama
  • Roberts, Josh
  • Cox, Chantel
  • Orr, Sarah
  • Hogan, Alison
  • Tiwari, Divya
  • Hann, Gail
  • Longland, Barbara
  • David, Owen
  • Bell, Jo
  • Ovington, Catherine
  • Rogers, Emily
  • Bower, Rachel
  • Keltos, Marketa
  • Cohen, David
  • Devine, Joseph
  • Alwis, Lankantha
  • Southworth, Lucy
  • Burgess, Laura
  • Lang, Matilda
  • Badiani, Bhavna
  • Guo, Fenglin
  • Oshodi, Anne
  • Owoyele, Emmanuelle
  • Epie, Norah
  • David, Anette
  • Mpelembue, Mushiya
  • Bathula, Rajaram
  • Abdul-Saheb, Mudhar
  • Chamberlain, Angela
  • Sudkeo, Varthi
  • Rashed, Khalid
  • Wood, Diane
  • Williams-Yesson, Barbara
  • Board, Joanne
  • De Bruijn, Sarah
  • Buckley, Clare
  • Board, Sarah
  • Allison, Joanna
  • Keeling, Elizabeth
  • Duckett, Tracey
  • Donaldson, Dave
  • Vickers, Carinna
  • Barron, Claire
  • Balian, Linda
  • Wilson, Jodhi
  • Edwards, Adam
  • England, Timothy
  • Hedstrom, Amanda
  • Bedford, Elizabeth
  • Harper, Margaret
  • Melikyan, Elina
  • Abbott, Wendy
  • Subramanian, Kashmira
  • Goldsworthy, Marie
  • Srinivasan, Meena
  • Yeomans, Angela
  • Donaldson, Denise
  • Hurford, Frances
  • Chapman, Riquella
  • Shahzad, Sana
  • David, Owen
  • Motherwell, Nicki
  • Tonks, Louise
  • Young, Rachel
  • Ghani, Usman
  • Mukherjee, Indranil
  • Dutta, Dipankar
  • Obaid, Mudhar
  • Brown, Pauline
  • Davis, Fiona
  • Ward, Deborah
  • Turfrey, Jennifer
  • Cartwright, Bethan
  • Topia, Bilal
  • Spurway, Judith
  • Collins, Kayleigh
  • Bakawala, Rehana
  • Hughes, Chloe
  • Oconnell, Susan
  • Hill, Linda
  • Chatterjee, Kausik
  • Webster, Tim
  • Haider, Syed
  • Rushworth, Pamela
  • Macleod, Fiona
  • Nallasivan, Arumugam
  • Perkins, Charlotte
  • Burns, Edel
  • Leason, Sandra
  • Carter, Tom
  • Seagrave, Samantha
  • Sami, Eman
  • Armstrong, Lisa
  • Naqvi, Syed Naseem
  • Hassan, Muhammad
  • Parkinson, Sharron
  • Mawer, Samantha
  • Darnbrook, Gillian
  • Booth, Carl
  • Hairsine, Brigid
  • Smith, Matthew
  • Williamson, Sue
  • Farquhar, Fiona
  • Esisi, Bernard
  • Cassidy, Tim
  • Mankin, Gavin
  • Mcclelland, Beverley
  • Bokhari, Maria
  • Sproates, David
  • Epstein, Elliot
  • Hurdowar, Steve
  • Blackburn, Ruth
  • Sukhdeep, Nazran
  • Razak, Saika
  • Osman, Khalid
  • Hashmi, Amina
  • Upton, Natasha
  • Harrington, Frances
  • Courtauld, Gillian
  • Schofield, Christine
  • Lucas, Linda
  • Adie, Katja
  • Bond, Kirsty
  • Mate, Abhijit
  • Skewes, Jo
  • James, Ali
  • Brodie, Carolyn
  • Johnson, Matthew
  • Allsop, Linda
  • Driver, Emma
  • Harris, Karina
  • Drake, Mark
  • Ellis, Sam
  • Maund, Bev
  • Thomas, Emma
  • Moore, Kimberley
  • Burn, Matthew
  • Hamilton, Adam
  • Mahalingam, Shageetha
  • Misra, Amulya
  • Reid, Farrah
  • Benford, Adrienne
  • Hilton, Derek
  • Hazell, Lorraine
  • Ofori, Keziah
  • Thomas, Anne Louise
  • Mathew, Moncy
  • Dayal, Sonia
  • Burn, Iona
  • Fotherby, Kenneth
  • Jennings-Preece, Karla
  • Willberry, Angela
  • Morgan, Debbie
  • Butler, Donna
  • Sahota, Gurminder
  • Kauldhar, Kelly
  • Ahmad, Nasar
  • Stevens, Angela
  • Das, Saugata
  • Bruce, David
  • Pai, Yogish
  • Nyo, Khin
  • Stephenson, Lynsey
  • Nendick, Richard
  • Rogers, Gill
  • Dhakal, Mahesh
  • Dima, Sofia
  • Brown, Ellen
  • Clayton, Susan
  • Gamble, Penny
  • Naeem, Muhammad
  • Hayman, Rachel
  • Burnip, Rachel
  • Earnshaw, Philip
  • Hargroves, David
  • Ransom, Barbara
  • Rudenko, Hannah
  • Balogun, Ibrahim
  • Griffiths, Kirsty
  • Mears, Kim
  • Webb, Tom
  • Cowie, Linda
  • Hammond, Tessa
  • Thomson, Audrey
  • Ceccarelli, Daniela
  • Chattha, Navraj
  • Beranova, Eva
  • Verrion, Anna
  • Gillian, Andrew
  • Schumacher, Natasha
  • Bahk, Anna
  • Walker, Susannah
  • Cvoro, Vera
  • Mccormick, Katrina
  • Chapman, Nicola
  • Pound, Susan
  • Cain, Rebecca
  • Mcauley, Sean
  • Couser, Mandy
  • Simpson, Maria
  • Tachtatzis, Athan
  • Ullah, Khalil
  • Sims, Don
  • Jones, Rachael
  • Smith, Jonathan
  • Tongue, Rebecca
  • Willmot, Mark
  • Sutton, Claire
  • Littleton, Edward
  • Khaira, Jattinder
  • Maiden, Susan
  • Cunningham, James
  • Green, Carole
  • Chin, Yin-May
  • Bates, Michelle
  • Ahlquist, Katherine
  • Kane, Ingrid
  • Breeds, Joanna
  • Sargent, Tenesa
  • Latter, Laura
  • Pitt Ford, Alexandra
  • Gainsborough, Nicola
  • Levett, Tom
  • Thompson, Philip
  • Barbon, Emma
  • Dunne, Angela
  • Hervey, Simon
  • Ragab, Suzanne
  • Sandell, Tracy
  • Dickson, Christine
  • Dube, Judith
  • Power, Sharon
  • Evans, Nick
  • Wadams, Beverley
  • Elitova, Savina
  • Aubrey, Beth
  • Garcia, Tatiana
  • Mcilmoyle, James
  • Jeffs, Carol
  • Dickinson, Christina
  • Ahmed, Anis
  • Kumar, Sanjeev
  • Frudd, Julie
  • Armer, Charlotte
  • Potter, Andrew
  • Donaldson, Stacey
  • Howard, Joanne
  • Jones, Kirsty
  • Dhar, Saikat
  • Collas, David
  • Sundayi, Saul
  • Denham, Lynn
  • Oza, Deepali
  • Walker, Elaine
  • Cunningham, James
  • Bhandari, Mohit
  • Ispoglou, Sissy
  • Evans, Rachel
  • Sharobeem, Kamel
  • Walton, Elaine
  • Shanu, Steven
  • Hayes, Anne
  • Howard-Brown, Jennifer
  • Billingham, Steven
  • Weir, Nic
  • Pressly, Vanessa
  • Wood, Emma
  • Sykes, Lucy
  • Howard, Gabriella
  • Burton, Holly
  • Crawford, Pam
  • Egerton, Shuna
  • Evans, Sue
  • Hakkak, Jasmine
  • Andrews, Janet
  • Lampard, Rebecca
  • Allen, Christopher
  • Walters, Ashleigh
  • Said, Rasha
  • Marigold, James Richard
  • Tsang, Sau-Mon
  • Creeden, Robyn
  • Cox, Chloe
  • Smith, Simon
  • Gartrell, Imogen
  • Smith, Fiona
  • Jenkins, Colin
  • Pryor, Joanna
  • Hedges, Andrew
  • Price, Fiona
  • Moseley, Linda
  • Mercer, Lily
  • Hughes, Claire
  • Mcgowan, Diane
  • Azim, Abul
  • White, Julie
  • Krasinska-Chavez, Milena
  • Chaplin, Shaun
  • Curtis, James
  • Singh, Deepwant
  • Imam, Javed
  • Nicolson, Anne
  • Alam, Sajid
  • Whitworth, Simon
  • Wood, Lisa
  • Warburton, Elizabeth
  • Kelly, Siobhan
  • Mcgee, Joanne
  • Markus, Hugh
  • Chandrasena, Denish
  • Hayden, Derek
  • Sesay, Juliana
  • Hayhoe, Helen
  • Bolton, Mark
  • Macdonald, Jane
  • Mitchell, Jenny
  • Farron, Charlotte
  • Amis, Elaine
  • Day, Diana
  • Culbert, Ainsley
  • Espanol, Ailene
  • Hannon, Niamh
  • Handley, Dominic
  • Finlay, Sarah
  • Crisp, Sarah
  • Whitehead, Lynne
  • Francis, Jobbin
  • Oconnell, Janice
  • Osborne, Emily
  • Beard, Rod
  • Krishnamurthy, Ramesh
  • Mokoena, Langanani
  • Sattar, Naweed
  • Myint, Min
  • Edwards, Michelle
  • Smith, Andrew
  • Corrigan, Paul
  • Byrne, Anthony
  • Blackburn, Joanne
  • Mcghee, Caroline
  • Smart, Amanda
  • Macleod, Malcolm
  • Donaldson, Fiona
  • Copeland, Claire
  • Wilson, Jill
  • Scott, Rhona
  • Fitzsimmons, Paul
  • Lopez, Paula
  • Wilkinson, Mark
  • Manoj, Aravindakshan
  • Cox, Penelope
  • Trainor, Leona
  • Fletcher, Glyn
  • Denny, Lisa
  • Kavanagh, Karen
  • Allsop, Hannah
  • Emsley, Hedley
  • Sultan, Sulaiman
  • Mcloughlin, Alison
  • Walmsley, Benjamin
  • Hough, Louise
  • Ahmed, Shakeel
  • Doyle, Donna
  • Gregary, Bindu
  • Raj, Sonia
  • Nagaratnam, Kirubananthan
  • Mannava, Neelima
  • Haque, Nyla
  • Shields, Norma
  • Preston, Kate
  • Mason, Geraldine
  • Short, Kirsty
  • Lumsdale, Gemma
  • Uitenbosch, Giulia
  • Sukys, Ugnius
  • Valentine, Stacey
  • Jarrett, David
  • Dodsworth, Kerry
  • Wands, Mary
  • Khan, Nisa
  • Tandy, Jane
  • Watkinson, Catrin
  • Golding, Wendy
  • Butler, Rebecca
  • Williams, Max
  • Davies, Yasmin
  • Yip, Keith
  • James, Claire
  • Suttling, Anne
  • Maney, Aditya
  • Gamble, Giles Edward
  • Hague, Adam
  • Charles, Bethan
  • Blane, Sujata
  • Duran, Beatriz
  • Lambert, Caroline
  • Stagg, Katherine
  • Whiting, Robert
  • Homan, Jane E
  • Brown, Sarah
  • Hussain, Malik
  • Harvey, Miriam
  • Graham, Libby
  • Foote, Leanne
  • Lane, Catherine
  • Kemp, Liz Joan
  • Rowe, Joy
  • Durman, Helen
  • Foot, Jayne
  • Brotherton, Lucy
  • Hunt, Nicholas
  • Pawley, Corinne
  • Whitcher, Alison
  • Sutton, Patrick
  • Mcdonald, Susan
  • Pak, Denys
  • Wiltshire, Alison
  • Jagger, Jennifer
  • Metcalf, Anthony K
  • Healey, Gail Louise
  • Balami, Joyce
  • Self, Clare Marie
  • Crofts, Melissa
  • Chakrabarti, Annie
  • Hmu, Chit
  • Ravenhill, Garth
  • Grimmer, Charmaine
  • Soe, Thandar
  • Keshet-Price, Jocelyn
  • Langley, Margaret
  • Potter, Ian
  • Tam, Pui-Lin
  • Macleod, Mary Joan
  • Cooper, Patricia
  • Christie, Michael
  • Irvine, Janice
  • Annison, Faye
  • Christie, David
  • Meneses, Celia
  • Johnson, Amber
  • Joyson, Anu
  • Nelson, Sandra
  • Taylor, Vicky
  • Reid, John
  • Clarke, Rebecca
  • Furnace, Jacqueline
  • Gow, Heather
  • Abousleiman, Youssif
  • Beadling, Tania
  • Collins, Sally
  • Jones, Stuart
  • Purcell, Jessica
  • Bloom, Samantha
  • Goshawk, Shelly
  • Landicho, Marcial
  • Sangaralingham, Sivatharshini
  • Begum, Yasmin
  • Mutton, Sherree
  • Munuswamy Vaiyapuri, Elangovan
  • Allen, Jane
  • Lowe, Jemma
  • Hughes, Martin
  • Wiggam, Ivan
  • Cuddy, Sarah
  • Tauro, Suzanne
  • Wells, Brian
  • Mohd Nor, Azlisham
  • Eglinton, Charlotte
  • Persad, Nicola
  • Kalita, Maggie
  • Weatherby, Stuart
  • Brown, Claire
  • Pace, Adrian
  • Lashley, Daniel
  • Marner, Mike
  • Weinling, Marie
  • Wilmshurst, Natasha
  • Waugh, Darren
  • Mucha, Anna
  • Shah, Alex
  • Baker, John
  • Westcott, Jacqueline
  • Cowan, Richard
  • Vasileiadis, Evangelos
  • Mumani, Samira
  • Parry, Anthea
  • Mason, Cathy
  • Holden, Melinda
  • Petrides, Katerina
  • Nishiyama, Tomoko
  • Mehta, Hina
  • Krishnan, Manju
  • Lynne, Dacey
  • Thomas, Lisa
  • Lynda, Connor
  • Hughes, Catherine
  • Clements, Clare
  • Williams, Rhys
  • Anjum, Tal
  • Sharon, Storton
  • Tucker, Susan
  • Jones, Paul
  • Colwill, Deanne
  • Thompson Jones, Helen
  • Chadha, Dinesh
  • Fairweather, Mark
  • Walstow, Deborah
  • Fong, Rosanna
  • Johnston, Stuart
  • Almadenboyle, Christine
  • Ross, Sarah
  • Carson, Shona
  • Nair, Priya
  • Tenbruck, Emily
  • Stirling, Mairi
  • Pusalkar, Aparna
  • Beadle, Hannah
  • Chan, Kelly
  • Dangri, Puneet
  • Asokanathan, Asaipillai
  • Rana, Anita
  • Gohil, Sunita
  • Massyn, Mark
  • Aruldoss, Prabhu
  • Cook, Angela
  • Crabtree, Karen
  • Dabbagh, Sura
  • Black, Toby
  • Clarke, Caroline
  • Mead, Denise
  • Fennelly, Ruth
  • Anthony, Alpha
  • Nardone, Linda
  • Dimartino, Victoria
  • Tribbeck, Michele
  • Broughton, David
  • Tryambake, Dinesh
  • Dixon, Lynn
  • Skotnicka, Agnieszka
  • Thompson, Jane
  • Whitehouse, Sarah
  • Sigsworth, Andrew
  • Wong, Jason
  • Annamalai, Arunkumar
  • Pagan, Julie
  • Affley, Brendan
  • Sunderland, Caroline
  • Goldenberg, Lynda
  • Khan, Atif
  • Wilkinson, Peter
  • Nari, Raad
  • Abbott, Lucy
  • Young, Emma
  • Shakhon, Amritpal
  • Lock, Sally
  • Stewart, Jack
  • Pereira, Rita
  • Dsouza, Margaret
  • Dunn, Sally
  • Mckenna, Anne-Marie
  • Cron, Nina
  • Kidd, Michelle
  • Hull, Grace
  • Bunworth, Kerry
  • Drummond, Graham
  • Mahawish, Karim
  • Hayes, Nicola
  • Connell, Lynne
  • Simpson, Jennifer
  • Penney, Helen
  • Punekar, Shuja
  • Nevinson, Joanne
  • Wareing, William
  • Ward, Jacqueline
  • Greenwood, Richard
  • Austin, Duncan
  • Banaras, Azra
  • Hogan, Carolin
  • Corbett, Thomas
  • Oji, Nnebuife
  • Elliott, Emma
  • Brezitski, Maria
  • Passeron, Nathalie
  • Howaniec, Laura
  • Watchurst, Caroline
  • Patel, Krishna
  • Erande, Renuka
  • Shah, Rahi
  • Sengupta, Nabarun
  • Metiu, Maria
  • Gonzalez, Celia
  • Funnell, Sarah
  • Margalef, Jordi
  • Peters, Gillian
  • Chadbourn, Indra
  • Sivakumar, Ramachandran
  • Saksena, Rajesh
  • Ketley-O'donel, Jane
  • Needle, Richard
  • Chinery, Elaine
  • Wright, Alison
  • Cook, Sue
  • Ngeh, Joseph
  • Proeschel, Harald
  • Cook, Paige
  • Ashcroft, Pauline
  • Sharpe, Simon
  • Jones, Stephanie
  • Jenkinson, Damian
  • Kelly, Deborah
  • Bray, Holly
  • Gunathilagan, Gunaratnam
  • Griffiths, Kirsty
  • Mears, Kim
  • Gillian, Andrew
  • Jones, Sally
  • Tilbey, Sorrell
  • Abubakar, Saidu
  • Beranova, Eva
  • Vassallo, Joseph
  • Leonard, Dee
  • Orrell, Lucy
  • Hasan, Aziz
  • Khan, Asif
  • Qamar, Sulmaaz
  • Graham, Susan
  • Hewitt, Emma
  • Awolesi, Jennifer
  • Haque, Muhammad
  • Kent, Alissa
  • Bradshaw, Elizabeth
  • Cooper, Martin
  • Wynter, Inez
  • Rajapakse, Anoja
  • Janbieh, Joumana
  • Nasar, Abu M
  • Wade, Lynne
  • Otter, Linda
  • Haigh, Steve
  • Burgoyne, Jamie-Rae
  • Boulton, Rebecca
  • Boulton, Andrew
  • Rayessa, Rayessa
  • Clarkson, Emma
  • Rhian, Horne
  • Fleming, Amy
  • Mitchelson, Kim
  • Lowthorpe, Vicki
  • Abdul-Hamid, Ahmed
  • Jones, Phil
  • Duggan, Claire
  • Hynes, Abigail
  • Nurse, Emma
  • Raza, Syed Abid
  • Jones, Sarah
  • Pallikona, Udaya
  • Edwards, Bleddyn
  • Morgan, Geraint
  • Dennett, Kirsty
  • Tench, Helen
  • Loosley, Ronda
  • Trugeon-Smith, Toby
  • Jones, Rhian
  • Williams, Richard
  • Robson, Donna
  • Mavinamane, Sunanda
  • Meenakshisundaram, Sanjeevi
  • Ranga, Lalitha
  • Dealing, Sharon
  • Hill, Andrew
  • Hargreaves, Margaret
  • Smith, Tom
  • Bate, Julie
  • Harrison, Linda
  • Kirthivasan, Ramanathan
  • Cannon, Emma
  • Topliffe, Joanne
  • Keskeys, Rebecca
  • Williams, Sarah
  • Mcneela, Fiona
  • Cairns, Frances
  • James, Thomas
  • Lyle, Amanda
  • Shah, Sheela
  • Zachariah, George
  • Fergey, Lauren
  • Smolen, Susan
  • Cooper, Lucy
  • Bohannan, Elizabeth
  • Omer, Siddiq
  • Amlani, Sageet
  • Hunter, Nadia
  • Hawkes-Blackburn, Melissa
  • Gulli, Giosue
  • Peacocke, Alice
  • Amero, Justine
  • Burova, Maria
  • Speirs, Ottilia
  • Levy, Steph
  • Francis, Lynda
  • Holland, Susan
  • Brotheridge, Sean
  • Lyon, Helen
  • Hare, Christine
  • Jackson, Samantha
  • Stephenson, Lorraine
  • Al Hussayni, Samer
  • Featherstone, James
  • Bwalya, Agness
  • Singh, Arun
  • Goorah, MN
  • Walford, Jamie
  • Bell, Angela
  • Kelly, Christine
  • Rusk, Darren
  • Sutton, Deborah
  • Patel, Farzana
  • Duberley, Stephen
  • Hayes, Kathryn
  • Hunt, Lorraine
  • El Nour, Ahmed
  • Cottrell, Poppy
  • Westmoreland, Jax
  • Honour, Sacha
  • Box, Chloe
  • Wood, Paul
  • Haritakis, Monica
  • Dyer, Simon
  • Brown, Lynne
  • Elliott, Kerry
  • Temlett, Emma
  • Paterson, John
  • Furness, Rosie
  • Young, Shelli
  • Orugun, Enoch
  • Brewer, Chris
  • Thornthwaite, Sarah
  • Crowther, Hannah
  • Glover, Rachel
  • Sein, Moe
  • Haque, Kashif
  • Gibson, Elspeth
  • Wong, Sam
  • Rotchell, Karen
  • Burton, Karen
  • Brookes, Lisa
  • Bailey, Linda
  • Leonard, Dee
  • Lindley, Chris
  • Murray, Abbi
  • Waltho, Karen
  • Holland, Maureen
  • Kumar, Pradeep
  • Harlekar, Purnima
  • Booth, Laura
  • Culmsee, Charlotte
  • Drew, Jade
  • Khan, Mohammad
  • Mackenzie, Nicola
  • Thomas, Carmel
  • Ritchie, Jane
  • Barker, James
  • Haley, Michael
  • Cotterill, Donna
  • Lane, Lynne
  • Little, Christine
  • Simmons, Dawn
  • Saunders, Glenn
  • Dymond, Harvey
  • Kidd, Sarah
  • Warinton, Rachel
  • Neves-Silva, Yara
  • Nevajda, Branimir
  • Villaruel, Michael
  • Umasankar, Udayaraj
  • Patel, Seema
  • Man, Anna
  • Christmas, Natasha
  • Rangasamy, Ravi
  • Ladner, Richard
  • Butt, Georgina
  • Alvares, Wilson
  • Gadi, Narasimha
  • Power, Michael
  • Wroath, Belinda
  • Dynan, Kevin
  • Wilson, David
  • Crothers, Sarah
  • Leonard, Catherine
  • Hagan, Samantha
  • Douris, Geraldine
  • Vahidassr, Djamil
  • Thompson, Alastair
  • Gallen, Brian
  • Mckenna, Shirley
  • Edwards, Collette
  • Mcgoldrick, Clare
  • Bhattad, Murdi
  • Kawafi, Khalil
  • Morse, Deborah
  • Jacob, Patricia
  • Turner, Lisa
  • Saravanan, Narayanamoorti
  • Johnson, Linda
  • Humphrey, Sadie
  • Namushi, Robert
  • Patel, Ramesh
  • Mclaughlin, Jemma
  • Omahony, Paul
  • Osikominu, Esther
  • Orefo, Chukwuka
  • Mcdonald, Chisha
  • Jones, Val
  • Makanju, Esther
  • Khan, Tabindah
  • Appiatse, Grace
  • Stone, Helena
  • Augustin, Martia
  • Wardale, Alicia
  • Salehin, Maqsud
  • Bailey, Duncan
  • Garcia-Alen, Luciano
  • Kalathil, Latheef
  • Tinsley, Sarah
  • Jones, Taya
  • Amor, Kelly
  • Ritchings, Andrew
  • Margerum, Emma
  • Horton, Jane
  • Miller, Richard
  • Gautam, Nireekshana
  • Meir, Julie
  • Jones, Amaryl
  • Putteril, Janet
  • Lepore, Mirella
  • Makanju, Esther
  • Gallifent, Rachel
  • Arundell, Laura-Louise
  • Mcredmond, Catherine
  • Goulding, Alicia
  • Nadarajan, Vivek
  • Laurence, Julia
  • Fung Lo, Su
  • Melander, Sabina
  • Nicholas, Paul
  • Woodford, Elizabeth
  • Mckenzie, Gillian
  • Le, Vietland
  • Crause, Jacolene
  • Luder, Robert
  • Bhargava, Maneesh
  • Shah, Rahi
  • Bhome, Girish
  • Johnson, Venetia V
  • Chesser, Dara
  • Bridger, Hayley
  • Murali, Elodie
  • Scott, Jon
  • Morrison, Susan
  • Burns, Amy
  • Graham, Julie
  • Duffy, Madeline
  • Ali, Khalid
  • Sargent, Tenesa
  • Pitcher, Emma
  • Gaylard, Jane
  • Newman, Julie
  • Punnoose, Sunil
  • Besley, Sarah
  • Purohit, Kirtan
  • Rees, Amy
  • Davy, Mark
  • Chohan, Osman
  • Khan, Muhammad Fozan
  • Walker, Rachel
  • Murray, Vicky
  • Bent, Charlotte
  • Oakley, Susan
  • Blight, Adrian
  • Peixoto, Cassilda
  • Jones, Suzanne
  • Livingstone, Gaybrielle
  • Butler, Fiona
  • Bradfield, Sally
  • Gordon, Laura
  • Schmit, Jenneke
  • Wijewardane, Anika
  • Edmunds, Tineke
  • Wills, Rebecca
  • Medcalf, Catherine
  • Argandona, Lucia
  • Cuenoud, Larissa
  • Hassan, Hanna
  • Erumere, Esther
  • Ocallaghan, Aidan
  • Gompertz, Patrick
  • Redjep, Ozlem
  • Auld, Grace
  • Howaniec, Laura
  • Song, Anna
  • Tarkas, Tillana
  • Kabash, Hashim
  • Hungwe, Rumbi

publication date

  • January 2019