Coincidence vs Cause: Cure in Three Glioblastoma Patients Treated with Brachytherapy Journal Articles uri icon

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  • Background:Very long term survival after diagnosis of malignant glioma has been described in individual case reports. Survival of more than 10 years is extremely rare, especially when identified in 3 out of 71 patients assigned to one arm of a randomized controlled trial.Patients:Three patients survived 11, 16, and 18 years following the diagnosis of glioblastoma and treatment with surgery, conventional fractionated radiation, and high-activity iodine-125 boost brachytherapy as part of a randomized controlled trial.Conclusion:Despite this apparent cause and effect relationship, statistical analysis shows no relationship between these cures and treatment with brachytherapy. Cure of glioblastoma remains rare.


  • Dehdashti, Amir R
  • Sharma, Sunjay
  • Laperriere, Normand
  • Bernstein, Mark

publication date

  • August 2007

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