Conference
Oral Naloxone for Methadone-induced Constipation: Preliminary Results of a Randomized Placebo-controlled Trial
Abstract
IntroductionConstipation is a very common and one of the most persistent side effects of opioids. In many cases constipation causes severe discomfort and puts limitations on methadone maintenance treatment (MMT). Conventional laxatives are not always effective and do not address the pathophysiological basis of constipation. It was suggested that opioid receptor antagonists with low oral bioavailability e.g. naloxone might reverse constipation …
Authors
Samokhvalov AV; Sproule B; Selby P; Rehm J
Volume
30
Publisher
Cambridge University Press (CUP)
Publication Date
March 2015
DOI
10.1016/s0924-9338(15)31469-3
Conference proceedings
European Psychiatry
ISSN
0924-9338