Journal article
Age-Dependent Variation in Glycosylation Features of Alpha-2-Macroglobulin
Abstract
Alpha-2-macroglobulin (A2M) is a glycosylated broad spectrum inhibitor of numerous proteases, including those involved in blood coagulation. Glycosylation characteristics can affect protein structure and function. This study compares glycosylation characteristics of A2M in newborn umbilical cord (NUCP) and adult pooled plasmas. Peptide N-Glycosidase F treatment was used to evaluate the total N-glycan content of the molecules. Neuraminidase …
Authors
Calvert L; Atkinson H; Berry L; Chan A
Journal
Cell Biochemistry and Biophysics, Vol. 77, No. 4, pp. 335–342
Publisher
Springer Nature
Publication Date
December 2019
DOI
10.1007/s12013-019-00883-4
ISSN
1085-9195