Omeprazole (20 mg daily) versus cimetidine (1200 mg daily) in duodenal ulcer healing and pain relief Academic Article uri icon

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abstract

  • We conducted a double-blind, randomized, parallel group study in 169 patients with acute duodenal ulcers to compare omeprazole, 20 mg daily, with cimetidine, 600 mg twice daily. After 2 wk, 58% of the omeprazole-treated patients and 46% of the cimetidine-treated patients were completely healed (p = 0.056). After 4 and 6 wk 84% and 88% healed with omeprazole, and 80% and 89% healed with cimetidine (p = NS). After 2 wk, pain was completely gone in 62% of the omeprazole-treated patients versus 46% of the cimetidine-treated patients (p = 0.04). Clinical or laboratory adverse events were reported in 6 (7%) of the omeprazole-treated patients and 11 (13%) of the cimetidine-treated patients (p = NS). An adverse event caused withdrawal of 1 patient on omeprazole (anxiety and depression) and 2 patients on cimetidine (diarrhea and fall in hemoglobin). We conclude that omeprazole (20 mg daily) resulted in a trend toward more rapid ulcer healing compared with a relatively high dose of cimetidine (600 mg b.i.d.), and was preferred by patients for relief of ulcer pain.

authors

  • Archambault, Andre P
  • Pare, Pierre
  • Bailey, Robert J
  • Navert, Henri
  • Williams, C Noel
  • Freeman, Hugh J
  • Baker, Selwyn J
  • Marcon, Norman E
  • Hunt, Richard H
  • Sutherland, Lloyd
  • Kepkay, David L
  • Saibil, Fred G
  • Hawken, Katherine
  • Farley, Alain
  • Levesque, Denis
  • Ferguson, James
  • Westin, Jan-Ake

publication date

  • May 1988