Atomic resolution map of the soluble amyloid beta assembly toxic surfaces

Soluble amyloid beta assemblies (Aβ _n ) are neurotoxic and play a central role in the early phases of the pathogenesis cascade leading to Alzheimer's disease. However, the current knowledge about the molecular determinants of Aβ _n toxicity is at best scant. Here, we comparatively analyze Aβ _n prepared in the absence or presence of a catechin library that modulates cellular toxicity. By combining solution NMR with dynamic light scattering, …