Anticoagulation therapy patterns for acute treatment of venous thromboembolism in GARFIELD ‐ VTE patients Academic Article uri icon

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abstract

  • BACKGROUND: Parenteral anticoagulants and vitamin K antagonists (VKAs) have constituted the cornerstone of venous thromboembolism (VTE) treatment. Meanwhile, direct oral anticoagulants (DOACs) provide physicians with an alternative. The Global Anticoagulant Registry in the FIELD (GARFIELD)-VTE observes real-world treatment practices. OBJECTIVES: Describe initial anticoagulation (AC) treatment patterns in VTE patients who received parenteral AC, VKAs, and/or DOACs within ±30 days of diagnosis. METHODS: VTE patients were categorized into parenteral AC only, parenteral AC with transition to VKA, VKA only, parenteral AC with transition to DOAC, and DOAC only. RESULTS: A total of 9647 patients were initiated on AC treatment alone. 4781 (49.6%) patients received DOACs ± parenteral ACs; 3187 (33.0%), VKA ± parenteral ACs; and 1679 (17.4%) parenteral ACs alone. Rivaroxaban was the most frequently used DOAC (79.4%). DOACs were more frequently used in North America/Australia (58.1%), Europe (52.2%), and Asia (47.6%) than in Latin America (29.7%) and the Middle East/South Africa (32.5%). In patients with suspected VTE, most received parenteral AC monotherapy (67.7%). Patients with deep vein thrombosis were more likely to receive DOACs alone than those with pulmonary embolism with or without deep vein thrombosis (36.2% vs 25.9%). Active cancer patients received parenteral AC alone (58.9%), with 25.5% receiving DOAC ± parenteral AC and 12.8% parenteral AC and VKA. A total of 46.5% of pregnant patients received parenteral AC monotherapy, 34.0% were treated with VKA ± parenteral AC, and 19.5% received a DOAC (± parenteral AC). CONCLUSION: AC treatment patterns vary by patient population, geographic region and site of VTE. Guidelines for AC therapy are not always adhered to.

authors

  • Haas, Sylvia
  • Ageno, Walter
  • Weitz, Jeffrey
  • Goldhaber, Samuel Z
  • Turpie, Alexander Graham Gri
  • Goto, Shinya
  • Angchaisuksiri, Pantep
  • Dalsgaard Nielsen, Joern
  • Kayani, Gloria
  • Zaghdoun, Audrey
  • Farjat, Alfredo E
  • Schellong, Sebastian
  • Bounameaux, Henri
  • Mantovani, Lorenzo G
  • Prandoni, Paolo
  • Kakkar, Ajay K
  • Loualidi, Ab
  • Colak, Abdurrahim
  • Bezuidenhout, Abraham
  • Abdool‐Carrim, Abu
  • Azeddine, Addala
  • Beyers, Adriaan
  • Dees, Adriaan
  • Mohamed, Ahmed
  • Aksoy, Ahmet
  • Abiko, Akihiko
  • Watanabe, Akinori
  • Krichell, Alan
  • Fernandez, Alberto Alfredo
  • Tosetto, Alberto
  • Khotuntsov, Alexey
  • Oropallo, Alisha
  • Slocombe, Alison
  • Kelly, Allan
  • Clark, Amanda
  • Gad, Amr
  • Arouni, Amy
  • Schmidt, Andor
  • Berni, Andrea
  • Kleiban, Andres Javier
  • Machowski, Andrew
  • Kazakov, Andrey
  • Galvez, Angel
  • Lockman, Ann
  • Falanga, Anna
  • Chauhan, Anoop
  • Riera‐Mestre, Antoni
  • Mazzone, Antonino
  • D'Angelo, Armando
  • Herdy, Artur
  • Kato, Atsushi
  • Ebrahim, Ayman Abd Elhamid
  • Salem, Mahmoud
  • Husin, Azlan
  • Erdelyi, Barbara
  • Jacobson, Barry
  • Amann‐Vesti, Beatrice
  • Battaloglu, Bektas
  • Wilson, Benedicte
  • Cosmi, Benilde
  • Francois, Bergmann Jean
  • Toufek, Berremeli
  • Hunt, Beverley
  • Natha, Bhavesh
  • Mustafa, Bisher
  • Kho, Bonnie Chi Shan
  • Carine, Boulon
  • Zidel, Brian
  • Dominique, Brisot
  • Christophe, Brousse
  • Trimarco, Bruno
  • Luo, Canhua
  • Alberto Cuneo, Carlos
  • Sanchez Diaz, Carlos Jerjes
  • Schwencke, Carsten
  • Cader, Cas
  • Yavuz, Celal
  • Javier Zaidman, Cesar
  • Lunn, Charles
  • Wu, Chau‐Chung
  • Toh, Cheng Hock
  • Chiang, Chern‐En
  • Elisa, Chevrier
  • Hsia, Chien‐Hsun
  • Huang, Chien‐Lung
  • Kwok, Chi‐Hang Kevin
  • Wu, Chih‐Cheng
  • Huang, Chi‐Hung
  • Ward, Chris
  • Opitz, Christian
  • Jeanneret‐Gris, Christina
  • Ha, Chung Yin
  • Huang, Chun‐Yao
  • Bidi, Claude Luyeye
  • Smith, Clifford
  • Brauer, Cornelia
  • Lodigiani, Corrado
  • Francis, Couturaud
  • Wu, Cynthia
  • Staub, Daniel
  • Theodoro, Daniel
  • Poli, Daniela
  • Acevedo, Riesco
  • Adler, David
  • Jimenez, David
  • Keeling, David
  • Scott, David
  • Imberti, Davide
  • Creagh, Desmond
  • Helene, Desmurs‐Clavel
  • Hagemann, Dirk
  • Le Roux, Dirk
  • Skowasch, Dirk
  • Belenky, Dmitry
  • Dorokhov, Dmitry
  • Petrov, Dmitry
  • Zateyshchikov, Dmitry
  • Prisco, Domenico
  • Møller, Dorthe
  • Kucera, Dusan
  • Esheiba, Ehab M
  • Panchenko, Elizaveta
  • Dominique, Elkouri
  • Dogan, Emre
  • Kubat, Emre
  • Diaz Diaz, Enrique
  • Tse, Eric Wai Choi
  • Yeo, Erik
  • Hashas, Erman
  • Grochenig, Ernst
  • Tiraferri, Eros
  • Blessing, Erwin
  • Michèle, Escande Orthlieb
  • Usandizaga, Esther
  • Porreca, Ettore
  • Ferroni, Fabian
  • Nicolas, Falvo
  • Ayala‐Paredes, Félix
  • Koura, Firas
  • Henry, Fitjerald
  • Cosmi, Franco
  • Erdkamp, Frans
  • Kamalov, Gadel
  • Dalmau, Garcia‐Bragado
  • Damien, Garrigues
  • Klein, Garry
  • Shah, Gaurand
  • Hollanders, Geert
  • Merli, Geno
  • Plassmann, Georg
  • Platt, George
  • Poirier, Germain
  • Sokurenko, German
  • Haddad, Ghassan
  • Ali, Gholam
  • Agnelli, Giancarlo
  • Gan, Gin Gin
  • Kaye‐Eddie, Grace
  • Le Gal, Gregoire
  • Allen, Gregory
  • Llamas Esperón, Guillermo Antonio
  • Jean‐Paul, Guillot
  • Gerofke, Hagen
  • Elali, Hallah
  • Burianova, Hana
  • Ohler, Hans‐Juergen
  • Wang, Haofu
  • Darius, Harald
  • Gogia, Harinder S
  • Striekwold, Harry
  • Gibbs, Harry
  • Hasanoglu, Hatice
  • Turker, Hatice
  • Franow, Hendrik
  • De Raedt, Herbert
  • Schroe, Herman
  • ElDin, Hesham Salah
  • Zidan, Hesham
  • Nakamura, Hiroaki
  • Kim, Ho Young
  • Lawall, Holger
  • Zhu, Hong
  • Tian, Hongyan
  • Yhim, Ho‐Young
  • Cate, Hugo
  • Hwang, Hun Gyu
  • Shim, Hyeok
  • Kim, Igor
  • Libov, Igor
  • Sonkin, Igor
  • Suchkov, Igor
  • Song, Ik‐Chan
  • Kiris, Ilker
  • Staroverov, Ilya
  • Looi, Irene
  • De La Azuela Tenorio, Isabel M
  • Savas, Ismail
  • Gordeev, Ivan
  • Podpera, Ivo
  • Lee, Jae Hoon
  • Sathar, Jameela
  • Welker, James
  • Beyer‐Westendorf, Jan
  • Kvasnicka, Jan
  • Vanwelden, Jan
  • Kim, JangYong
  • Svobodova, Jaromira
  • Gujral, Jaspal
  • Marino, Javier
  • Galvar, Javier Tristan
  • Kassis, Jeannine
  • Kuo, Jen‐Yuan
  • Shih, Jhih‐Yuan
  • Kwon, JiHyun
  • Joh, Jin Hyun
  • Park, Jin Hyun
  • Kim, Jin Seok
  • Yang, Jinghua
  • Krupicka, Jiri
  • Lastuvka, Jiri
  • Pumprla, Jiri
  • Vesely, Jiri
  • Carlos Souto, Joan
  • Antônio Correa, João
  • Duchateau, Johan
  • Fletcher, John Perry
  • Toro, Jorge
  • Toro, Jorge
  • Chavez Paez, Jorge Guillermo
  • Araujo Filho, Jose Dalmo
  • Saraiva, Jose
  • Diaz Peromingo, Jose Antonio
  • Gomez Lara, Jose
  • Luis Fedele, Jose
  • Maria Surinach, Jose
  • Chacko, Joseph
  • Antonio Muntaner, Juan
  • Álvarez Benitez, Juan Carlos
  • Hoyos Abril, Juan Moreno
  • Humphrey, Julian
  • Bono, Julio
  • Kanda, Junji
  • Boondumrongsagoon, Juree
  • Yiu, Kai Hang
  • Chansung, Kanchana
  • Boomars, Karin
  • Burbury, Kate
  • Kondo, Katsuhiro
  • Karaarslan, Kemal
  • Takeuchi, Kensuke
  • Kroeger, Knut
  • Zrazhevskiy, Konstantin
  • Svatopluk, Koscál
  • Shyu, Kou‐Gi
  • Vandenbosch, Kristel
  • Chang, Kuan‐Cheng
  • Chiu, Kuan‐Ming
  • Jean‐Manuel, Kubina
  • Wern, Kwan Jing
  • Ueng, Kwo‐Chang
  • Norasetthada, Lalita
  • Binet, Laure
  • Chew, Lee Ping
  • Zhang, Lei
  • Cristina, Leone Maria
  • Tick, Lidwine
  • Beatriz Schiavi, Lilia
  • Wong, Lily Lee Lee
  • Borges, Lohana
  • Botha, Louis
  • Capiau, Luc
  • Timmermans, Luc
  • Eduardo López, Luciano
  • Ria, Luigi
  • Hernandez Blasco, Luis Manuel
  • Guzman, Luis Alberto
  • Flota Cervera, Luis
  • Isabelle, Mahe
  • Monreal Bosch, Manuel
  • Rios Ibarra, Manuel
  • Núñez Fernandez, Manuel
  • Carrier, Marc
  • Raul Barrionuevo, Marcelo
  • Alcocer Gamba, Marco Antonio
  • Cattaneo, Marco
  • Moia, Marco
  • Bowers, Margaret
  • Chetanachan, Mariam
  • Berli, Mario Alberto
  • Fixley, Mark
  • Faghih, Markus
  • Stuecker, Markus
  • Schul, Marlin
  • Banyai, Martin
  • Koretzky, Martin
  • Myriam, Martin
  • Gaffney, Mary Elizabeth
  • Hirano, Masao
  • Kanemoto, Masashi
  • Nakamura, Mashio
  • Tahar, Mersel
  • Emmanuel, Messas
  • Kovacs, Michael
  • Leahy, Michael
  • Levy, Michael
  • Munch, Michael
  • Olsen, Michael
  • De Pauw, Michel
  • Gustin, Michel
  • Van Betsbrugge, Michiel
  • Boyarkin, Mikhail
  • Homza, Miroslav
  • Koto, Modise
  • Abdool‐Gaffar, Mohamed
  • Nagib, Mohamed Ayman Fakhry
  • El‐Dessoki, Mohamed
  • Khan, Mohamed
  • Mohamed, Monniaty
  • Kim, Moo Hyun
  • Lee, Moon‐Hee
  • Soliman, Mosaad
  • Ahmed, Mostafa Shawky
  • Bary, Mostafa Soliman Abd
  • Moustafa, Moustafa A
  • Hameed, Muhammad
  • Kanko, Muhip
  • Majumder, Mujibur
  • Zubareva, Nadezhda
  • Mumoli, Nicola
  • Abdullah, Nik Azim Nik
  • Makruasi, Nisa
  • Paruk, Nishen
  • Kanitsap, Nonglak
  • Duda, Norberto
  • Nordin, Nordiana
  • Nyvad, Ole
  • Barbarash, Olga
  • Gurbuz, Orcun
  • Vilamajo, Oscar Gomez
  • Nandayapa Flores, Oscar
  • Gur, Ozcan
  • Oto, Oztekin
  • Javier Marchena, Pablo
  • Carroll, Patrick
  • Lang, Pavel
  • MacCallum, Peter
  • Bilderling, Peter Baron
  • Blombery, Peter
  • Verhamme, Peter
  • Jansky, Petr
  • Bernadette, Peuch
  • De Vleeschauwer, Philippe
  • Hainaut, Philippe
  • Ferrini, Piera Maria
  • Iamsai, Piriyaporn
  • Christian, Ponchaux
  • Viboonjuntra, Pongtep
  • Rojnuckarin, Ponlapat
  • Ho, Prahlad
  • Mutirangura, Pramook
  • Wells, Rachel
  • Martinez, Rafael
  • Miranda, Raimundo Tirado
  • Kroening, Ralf
  • Ratsela, Rapule
  • Reyes, Raquel Lopez
  • Diaz de Leon, Raul Franco
  • Wong, Raymond Siu Ming
  • Alikhan, Raz
  • Jerwan‐Keim, Reinhold
  • Otero, Remedios
  • Murena‐Schmidt, Renate
  • Canevascini, Reto
  • Ferkl, Richard
  • White, Richard
  • Van Herreweghe, Rika
  • Santoro, Rita
  • Klamroth, Robert
  • Mendes, Robert
  • Prosecky, Robert
  • Cappelli, Roberto
  • Spacek, Rudolf
  • Singh, Rupesh
  • Griffin, Sam
  • Na, Sang Hoon
  • Chunilal, Sanjeev
  • Middeldorp, Saskia
  • Nakazawa, Satoshi
  • Toh, See Guan
  • Christophe, Seinturier
  • Isbir, Selim
  • Raymundo, Selma
  • Ting, Seng Kiat
  • Motte, Serge
  • Aktogu, Serir Ozkan
  • Donders, Servaas
  • Cha, Seung Ick
  • Nam, Seung‐Hyun
  • Marie‐Antoinette, Sevestre‐Pietri
  • Maasdorp, Shaun
  • Sun, Shenghua
  • Wang, Shenming
  • Essameldin, Sherif Mohamed
  • Sholkamy, Sherif Mohamed
  • Kuki, Shintaro
  • Yoshida, Shuichi
  • Matsuoka, Shunzo
  • McRae, Simon
  • Watt, Simon
  • Patanasing, Siriwimon
  • Jean‐Léopold, Siwe‐Nana
  • Wongkhantee, Somchai
  • Bang, Soo‐Mee
  • Testa, Sophie
  • Zemek, Stanislav
  • Behrens, Steffen
  • Dominique, Stephan
  • Mellor, Stuart
  • Singh, Suaran Singh Gurcharan
  • Datta, Sudip
  • Chayangsu, Sunee
  • Solymoss, Susan
  • Everington, Tamara
  • Abdel‐Azim, Tarek Ahmed Adel
  • Suwanban, Tawatchai
  • Adademir, Taylan
  • Hart, Terence
  • Béatrice, Terriat
  • Luvhengo, Thifhelimbilu
  • Horacek, Thomas
  • Zeller, Thomas
  • Boussy, Tim
  • Reynolds, Tim
  • Biss, Tina
  • Chao, Ting‐Hsing
  • Casabella, Tomas Smith
  • Onodera, Tomoya
  • Numbenjapon, Tontanai
  • Gerdes, Victor
  • Cech, Vladimir
  • Krasavin, Vladimir
  • Tolstikhin, Vladimir
  • Bax, WA
  • Malek, Wagih Fawzy Abdel
  • Ho, Wai Khoon
  • Pharr, Walter
  • Jiang, Weihong
  • Lin, Wei‐Hsiang
  • Zhang, Weihua
  • Tseng, Wei‐Kung
  • Lai, Wen‐Ter
  • De Backer, Wilfried
  • Haverkamp, Wilhelm
  • Yoshida, Winston
  • Korte, Wolfgang
  • Choi, Won II
  • Kim, Yang‐Ki
  • Tanabe, Yasuhiro
  • Ohnuma, Yasushi
  • Mun, Yeung‐Chul
  • Balthazar, Yohan
  • Park, Yong
  • Shibata, Yoshisato
  • Burov, Yuriy
  • Subbotin, Yuriy
  • Coufal, Zdenek
  • Yang, Zhenwen
  • Jing, Zhicheng
  • Jing, Zhicheng
  • Yang, Zhongqi

publication date

  • October 2019

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