Journal article
Evaluation of the inverse electron demand Diels-Alder reaction in rats using a scandium-44-labelled tetrazine for pretargeted PET imaging
Abstract
BackgroundPretargeted imaging allows the use of short-lived radionuclides when imaging the accumulation of slow clearing targeting agents such as antibodies. The biotin-(strept)avidin and the bispecific antibody-hapten interactions have been applied in clinical pretargeting studies; unfortunately, these systems led to immunogenic responses in patients. The inverse electron demand Diels-Alder (IEDDA) reaction between a radiolabelled tetrazine …
Authors
Edem PE; Sinnes J-P; Pektor S; Bausbacher N; Rossin R; Yazdani A; Miederer M; Kjær A; Valliant JF; Robillard MS
Journal
EJNMMI Research, Vol. 9, No. 1,
Publisher
Springer Nature
Publication Date
December 2019
DOI
10.1186/s13550-019-0520-y
ISSN
2191-219X