Antidepressant Treatment of Depression: A Metaanalysis Journal Articles

abstract

• Objective: To carry out a metaanalysis of antidepressant studies to calculate the effect sizes for antidepressant effect in depressive disorder. Method: A metaanalysis of all antidepressant studies that included an active comparison drug as well as placebo was used to calculate the effect size. Articles were selected from a MEDLINE search for the period January 1966 to June 1995. Forty-nine studies were included in the metaanalysis. Results: The effect sizes for antidepressant treatment are moderately larger than for placebo. A larger effect size was observed in studies where objective diagnostic criteria for depression were used. Conclusions: We conclude that the superior efficacy of antidepressants over placebo can be demonstrated.

authors

• Joffe, Russell
• Sokolov, Stephen
• Streiner, David Lloyd

status

• published 

publication date

• December 1996

has subject area

• 11 Medical and Health Sciences (FoR)
• 17 Psychology and Cognitive Sciences (FoR)
• Antidepressive Agents (MeSH)
• Depressive Disorder (MeSH)
• Humans (MeSH)
• Personality Inventory (MeSH)
• Psychiatry (Science Metrix)
• Randomized Controlled Trials as Topic (MeSH)
• Treatment Outcome (MeSH)

published in

• Canadian Journal of Psychiatry  Journal

keywords

• Antidepressive Agents
• Depressive Disorder
• Humans
• Personality Inventory
• Randomized Controlled Trials as Topic
• Treatment Outcome

Digital Object Identifier (DOI)

• 10.1177/070674379604101002

PubMed ID

• 8978938

start page

• 613

end page

• 616

volume

• 41

issue

• 10