WFSBP guidelines on how to grade treatment evidence for clinical guideline development

OBJECTIVE AND METHODS: This paper reviews sources of data typically used in guideline development, available grading systems, their pros and cons, and the methods for evaluating risks of bias in publications, and proposes a revised method for grading evidence and recommendations for use in development of clinical treatment guidelines. RESULTS: The new World Federation of Societies of Biological Psychiatry (WFSBP) grading system allows guideline …