Journal article
Mechanisms of cardiovascular risk reduction with ramipril: insights from HOPE and HOPE substudies
Abstract
Angiotensin converting enzyme (ACE) inhibitors decrease angiotensin formation, prevent breakdown of bradykinin, and may also act on other peptides of the renin-angiotensin system. Thus, these agents have many effects that can potentially protect the coronary and peripheral vascularature. Which of these “theoretical” mechanisms account for the clinical benefit observed in The Heart Outcomes Prevention Evaluation (HOPE) trial? While the answer to …
Authors
Lonn E; Gerstein HC; Smieja M; Mann JFE; Yusuf S
Journal
European Heart Journal Supplements, Vol. 5, No. suppl_A, pp. a43–a48
Publisher
Oxford University Press (OUP)
Publication Date
January 2003
DOI
10.1016/s1520-765x(03)90063-0
ISSN
1520-765X