Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke: a clinical practice guideline Academic Article uri icon

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  • What is the role of dual antiplatelet therapy after high risk transient ischaemic attack or minor stroke? Specifically, does dual antiplatelet therapy with a combination of aspirin and clopidogrel lead to a greater reduction in recurrent stroke and death over the use of aspirin alone when given in the first 24 hours after a high risk transient ischaemic attack or minor ischaemic stroke? An expert panel produced a strong recommendation for initiating dual antiplatelet therapy within 24 hours of the onset of symptoms, and for continuing it for 10-21 days. Current practice is typically to use a single drug


  • O'Donnell, Martin
  • Prasad, Kameshwar
  • Siemieniuk, Reed
  • Hao, Qiukui
  • Guyatt, Gordon
  • O’Donnell, Martin
  • Lytvyn, Lyubov
  • Heen, Anja Fog
  • Agoritsas, Thomas
  • Vandvik, Per Olav
  • Gorthi, Sankar Prasad
  • Fisch, Loraine
  • Jusufovic, Mirza
  • Muller, Jennifer
  • Booth, Brenda
  • Horton, Eleanor
  • Fraiz, Auxiliadora
  • Siemieniuk, Jillian
  • Fobuzi, Awah Cletus
  • Katragunta, Neelima
  • Rochwerg, Bram

publication date

  • December 18, 2018