Journal article
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
Abstract
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis …
Authors
Giri A; Hellwege JN; Keaton JM; Park J; Qiu C; Warren HR; Torstenson ES; Kovesdy CP; Sun YV; Wilson OD
Journal
Nature Genetics, Vol. 51, No. 1, pp. 51–62
Publisher
Springer Nature
Publication Date
January 2019
DOI
10.1038/s41588-018-0303-9
ISSN
1061-4036