Bipolar disorder and 1513A>C P2RX7 polymorphism frequency Academic Article uri icon

  •  
  • Overview
  •  
  • Research
  •  
  • Identity
  •  
  • Additional Document Info
  •  
  • View All
  •  

abstract

  • Although the etiology of Bipolar Disorder (BD) remains unknown, a strong genetic component to the pathogenesis and risk for this disorder has been widely hypothesized. Several risk genes for BD have been identified; of these, the purinergic P2 × 7 receptor (P2 × 7R) constitutes a pro-inflammatory receptor and a potential risk gene candidate. The purpose of the present study was to assess the frequency of the 1513 A > C P2RX7 polymorphism (rs3751143; Glu496Ala), which leads to receptor loss-of-function, in 154 BD patients versus 184 control subjects. The existence of a differential modulation of P2 × 7R was also analyzed in 22 euthymic BD patients, in comparison to 18 healthy controls. Our data show a decrease in 1513C allele frequency (p = 0.045) and a potential increase in 1513 A A/AC (p = 0.055) genotype frequency in BD patients, compared to controls, indicating an enhanced function of the pro-inflammatory P2 × 7 receptor in BD subjects. Interestingly, no differences in P2RX7 gene and protein expression were found between euthymic BD patients and matched healthy controls. In conclusion, our results suggest that P2 × 7R might play a role in the pathophysiology of BD and add new information regarding this receptor as a potential biomarker for the prediction and diagnosis of the disorder.

authors

  • Gubert, Carolina
  • Andrejew, Roberta
  • Jacintho Moritz, Cesar Eduardo
  • Dietrich, Fabricia
  • Vasconcelos-Moreno, Mirela Paiva
  • dos Santos, Bárbara Tietböhl Martins Quadros
  • Fijtman, Adam
  • Kauer-Sant’Anna, Márcia
  • Kapczinski, Flavio
  • da Silva Magalhães, Pedro Vieira
  • Battastini, Ana Maria Oliveira

publication date

  • February 2019