Subsensitivity of the norepinephrine receptor-coupled adenylate cyclase system in brain: Effects of Nisoxetine versus fluoxetine Academic Article uri icon

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  • Chronic administration of the norepinephrine (NE) reuptake inhibitor nisoxetine reduced the sensitivity of the NE receptor-coupled adenylate cyclase system in rat cortex. This subsensitivity, unlike that caused by desipramine (DMI), was not related to a reduction in specific beta-adrenergic receptor binding. The specific serotonin reuptake inhibitor fluoxetine had no effect on either neurohormonal sensitivity or 3H-dihydroalprenolol binding.


  • Mishra, Ram
  • Mishira, Radhakanta
  • Janowsky, Aaron
  • Sulser, Fridolin

publication date

  • December 1979