Conference
Routine clinical care data for population pharmacokinetic modeling: the case for Fanhdi/Alphanate in hemophilia A patients
Abstract
Fanhdi/Alphanate is a plasma derived factor VIII concentrate used for treating hemophilia A, for which there has not been any dedicated model describing its pharmacokinetics (PK). A population PK model was developed using data extracted from the Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) project. WAPPS-Hemo provided individual PK profiles for hemophilia patients using sparse observations as provided in routine …
Authors
Chelle P; Yeung CHT; Bonanad S; Morales Muñoz JC; Ozelo MC; Megías Vericat JE; Iorio A; Spears J; Mir R; Edginton A
Volume
46
Pagination
pp. 427-438
Publisher
Springer Nature
Publication Date
October 2019
DOI
10.1007/s10928-019-09637-4
Conference proceedings
Journal of Pharmacokinetics and Pharmacodynamics
Issue
5
ISSN
1567-567X