Journal article
Dual effects of SK&F 96365 in human leukemic HL-60 cells Inhibition of calcium entry and activation of a novel cation influx pathway
Abstract
The effects of the receptor-mediated Ca2+ entry blocker, SK&F 96365 on thapsigargin (TSG)-induced Ca2+ entry in fura-2-loaded HL-60 cells were studied. After Ca2+ release induced by 30 nM TSG, readmission of Ca2+ resulted in a sustained Ca2+ entry, which could be partially inhibited by 1-3 microM SK&F 96365. Surprisingly, SK&F 96365 at 30-100 microM, instead of causing a stronger inhibition, actually promoted Ca2+ entry. Furthermore, at 16-100 …
Authors
Leung Y-M; Kwan C-Y; Loh T-T
Journal
Biochemical Pharmacology, Vol. 51, No. 5, pp. 605–612
Publisher
Elsevier
Publication Date
March 1996
DOI
10.1016/s0006-2952(95)02181-7
ISSN
0006-2952