Airway smooth muscle

It has been recognised for some considerable time that contraction of airway smooth muscle is largely responsible for the bronchospasm that is a characteristic feature of the acute phase of an asthmatic attack. It is also well accepted that airway smooth muscle of asthmatic subjects is hyperresponsive to a wide range of provoking stimuli. One might anticipate, therefore, that a substantial amount would be known about the physiological role of …