Journal article
Increased airway responsiveness to inhaled methacholine in a rat model of chronic bronchitis.
Abstract
Chronic exposure of rats to high concentrations of SO2 gas causes pathologic changes in airway similar to those seen in human chronic bronchitis. The purpose of this study was to examine the pulmonary mechanical correlates of these changes and to quantify the extent of mucous hypersecretion by measuring changes in mucous glycoproteins. Female Sprague-Dawley rats were exposed to 250 ppm SO2 gas, 5 h/d, 5 d/wk, for a period of 4 wk. Control rats …
Authors
Shore S; Kobzik L; Long NC; Skornik W; Van Staden CJ; Boulet L; Rodger IW; Pon DJ
Journal
American Journal of Respiratory and Critical Care Medicine, Vol. 151, No. 6, pp. 1931–1938
Publisher
American Thoracic Society
Publication Date
June 1995
DOI
10.1164/ajrccm.151.6.7767542
ISSN
1073-449X