17HSD 2 may be higher in African-American breast cancer and is associated with estrogen receptor-negative tumors. Academic Article uri icon

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abstract

  • BACKGROUND: African-American women develop more aggressive breast cancers and at an earlier age compared with Caucasian women. MATERIALS AND METHODS: We compared gene expression profiles of breast cancer cell lines that were developed from African-American and Caucasian patients to identify biological differences in breast cancers that develop in these groups. Real-time PCR was used to evaluate mRNA expression in cell lines and in a series of breast cancer cases. Gene microarray signal intensities were also analyzed in the International Genomics Consortium Expression Project for Oncology (expO) dataset. RESULTS: 17,-Hydroxysteroid dehydrogenase type 2 (17HSD 2) gene and mRNA expression were significantly higher in the African-American cell lines (p<0.05). However, 17HSD 2 expression did not differ significantly between the two cohorts in either our clinical series or the expO dataset. 17HSD 2 expression was found to be predictive of younger age at diagnosis and estrogen receptor status. CONCLUSION: Overexpression of 17HSD 2 in African-American breast cancer may contribute to the increased proportion of estrogen receptor-negative breast cancers and worse clinical outcome among African-American patients.

authors

  • Yaeger, Rona
  • Nolan, Patricia
  • Su, Tao
  • Avila-Bront, Alexa
  • Wang, Xiaomei
  • Cheung, Ying Kuen K
  • Liu, Hui
  • Rangarajan, Vibhav S
  • Hibshoosh, Hanina
  • Powell, Charles A
  • Joe, Andrew K

publication date

  • September 2007