Journal article
Studies on the pharmacokinetics and pharmacodynamics of atenolol in man
Abstract
The non-stimulant cardioselective beta adrenocepter antagonist atenolol has been studied in volunteers in order to define its pharmacokinetic characteristics. Atenolol (100 and 200 mg orally) is rapidly absorbed, reductions in heart rate and systolic pressure being observed in 30 min. The effect persists for up to 8 h. Over 85% of an intravenous dose is excreted in urine within 24 h but only 50% of an oral dose. The bioavailability of …
Authors
Fitzgerald JD; Ruffin R; Smedstad KG; Roberts R; McAinsh J
Journal
European Journal of Clinical Pharmacology, Vol. 13, No. 2, pp. 81–89
Publisher
Springer Nature
Publication Date
3 1978
DOI
10.1007/bf00609750
ISSN
0031-6970