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Reciprocal cellular cross-talk within the tumor...
Journal article

Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity

Abstract

John Bell and colleagues report that cross-talk between tumor and cancer-associated fibroblasts mediated by FGF2 can enhance efficacy of oncolytic virotherapy.

Authors

Ilkow CS; Marguerie M; Batenchuk C; Mayer J; Ben Neriah D; Cousineau S; Falls T; Jennings VA; Boileau M; Bellamy D

Journal

Nature Medicine, Vol. 21, No. 5, pp. 530–536

Publisher

Springer Nature

Publication Date

May 1, 2015

DOI

10.1038/nm.3848

ISSN

1078-8956

Associated Experts

Brian Lichty

Associate Professor, Faculty of Health Sciences
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Labels

Fields of Research (FoR)

32 Biomedical and clinical sciences3211 Oncology and Carcinogenesis42 Health sciences

Medical Subject Headings (MeSH)

AgedAnimalsAntiviral AgentsCell Line, TumorChlorocebus aethiopsCoculture TechniquesFemaleFibroblast Growth Factor 2FibroblastsGreen Fluorescent ProteinsHumansLung NeoplasmsMaleMiceMicroscopy, FluorescenceMiddle AgedNeoplasm TransplantationOncolytic VirotherapyOncolytic VirusesOvarian NeoplasmsSignal TransductionStromal CellsTransforming Growth Factor betaTumor MicroenvironmentVero Cells
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