Journal article
The Effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Corticotrophin-Releasing Hormone, Arginine Vasopressin, and Pro-opiomelanocortin mRNA Levels in the Hypothalamus of the Cynomolgus Monkey
Abstract
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental contaminant that has profound deleterious effects on development and reproduction. TCDD may act at one or more levels to alter the hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes. The objective of this study was to investigate whether TCDD modulates neuroendocrine systems by altering gene expression of arginine vasopressin (AVP), …
Authors
Shridhar S; Farley A; Reid RL; Foster WG; Van Vugt DA
Journal
Toxicological Sciences, Vol. 63, No. 2, pp. 181–188
Publisher
Oxford University Press (OUP)
Publication Date
October 1, 2001
DOI
10.1093/toxsci/63.2.181
ISSN
1096-6080
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Administration, OralAnimalsArginine VasopressinCorticotropin-Releasing HormoneFemaleHistocytochemistryHydrocortisoneHypothalamusIn Situ HybridizationMacaca fascicularisParaventricular Hypothalamic NucleusPolychlorinated DibenzodioxinsPro-OpiomelanocortinProgesteroneRNA, MessengerRadioimmunoassayRandom AllocationSupraoptic NucleusTime Factors