Journal article
Structure of the Human 3α-Hydroxysteroid Dehydrogenase Type 3 in Complex with Testosterone and NADP at 1.25-Å Resolution*
Abstract
The first crystallographic structure of human type 3 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD3, AKR1C2), an enzyme playing a critical role in steroid hormone metabolism, has been determined in complex with testosterone and NADP at 1.25-A resolution. The enzyme's 17beta-HSD activity was studied in comparison with its 3alpha-HSD activity. The enzyme catalyzes the inactivation of dihydrotestosterone into 5alpha-androstane-3alpha,17beta-diol …
Authors
Nahoum V; Gangloff A; Legrand P; Zhu D-W; Cantin L; Zhorov BS; Luu-The V; Labrie F; Breton; Lin S-X
Journal
Journal of Biological Chemistry, Vol. 276, No. 45, pp. 42091–42098
Publisher
Elsevier
Publication Date
11 2001
DOI
10.1074/jbc.m105610200
ISSN
0021-9258