Journal article
Prognostic Impact of the Neutrophil-to-Lymphocyte Ratio in Men With Metastatic Castration-Resistant Prostate Cancer
Abstract
BACKGROUND: We retrospectively evaluated the prognostic impact of neutrophil-lymphocyte ratio (NLR) as a marker for inflammatory and immune state in men with progressive metastatic castration resistant prostate cancer (mCRPC) following docetaxel.
METHODS: The SUN-1120 phase III trial comparing prednisone combined with sunitinib (n = 584) or placebo (n = 289) for mCRPC following docetaxel-based chemotherapy was evaluated. The arms were combined …
Authors
Sonpavde G; Pond GR; Armstrong AJ; Clarke SJ; Vardy JL; Templeton AJ; Wang S-L; Paolini J; Chen I; Chow-Maneval E
Journal
Clinical Genitourinary Cancer, Vol. 12, No. 5, pp. 317–324
Publisher
Elsevier
Publication Date
October 2014
DOI
10.1016/j.clgc.2014.03.005
ISSN
1558-7673
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultAgedAged, 80 and overAlkaline PhosphataseAntineoplastic Combined Chemotherapy ProtocolsDisease ProgressionDocetaxelHemoglobinsHumansIndolesInflammationKaplan-Meier EstimateL-Lactate DehydrogenaseLymphocyte CountLymphocytesMaleMiddle AgedNeutrophilsPlacebosPrednisonePrognosisProportional Hazards ModelsProstate-Specific AntigenProstatic Neoplasms, Castration-ResistantPyrrolesRetrospective StudiesSunitinibTaxoids