Transforming Growth Factor-β: Importance in Long-Term Peritoneal Membrane Changes Conferences

abstract

• We have provided evidence from adenovirus-mediated gene transfer to the peritoneum that transforming growth factor-β1 mimics many of the functional and structural changes in the peritoneum in patients on long-term peritoneal dialysis, including fibrosis, increased submesothelial thickness, angiogenesis, increased solute transport, and ultrafiltration dysfunction. We review several key properties of this important fibrogenic molecule.

authors

• Margetts, Peter
• Oh, Kook-Hwan
• Kolb, Martin Rainer

status

• published 

publication date

• February 2005

has subject area

• Humans (MeSH)
• Peritoneal Diseases (MeSH)
• Peritoneum (MeSH)
• Transforming Growth Factor beta (MeSH)
• Transforming Growth Factor beta1 (MeSH)

published in

• Advances in peritoneal dialysis. Conference on Peritoneal Dialysis  Journal

presented at event

• 1st Joint Congress of the International-Society-for-Peritoneal-Dialysis/European Peritoneal Dialysis Meeting  Conference

keywords

• Humans
• Peritoneal Diseases
• Peritoneum
• Transforming Growth Factor beta
• Transforming Growth Factor beta1

Digital Object Identifier (DOI)

• 10.1177/089686080502503s04

PubMed ID

• 16048248

start page

• 15

end page

• 17

volume

• 25

issue

• 3_suppl