Journal article
Increased deposition of chondroitin/dermatan sulfate glycosaminoglycan and upregulation of β1,3-glucuronosyltransferase I in pulmonary fibrosis
Abstract
Pulmonary fibrosis (PF) is characterized by increased deposition of proteoglycans (PGs), in particular core proteins. Glycosaminoglycans (GAGs) are key players in tissue repair and fibrosis, and we investigated whether PF is associated with changes in the expression and structure of GAGs as well as in the expression of β1,3-glucuronosyltransferase I (GlcAT-I), a rate-limiting enzyme in GAG synthesis. Lung biopsies from idiopathic pulmonary …
Authors
Venkatesan N; Ouzzine M; Kolb M; Netter P; Ludwig MS
Journal
American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol. 300, No. 2, pp. l191–l203
Publisher
American Physiological Society
Publication Date
February 2011
DOI
10.1152/ajplung.00214.2010
ISSN
1040-0605
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsBleomycinCells, CulturedChondroitin SulfatesDermatan SulfateDisease Models, AnimalFibroblastsGlucuronosyltransferaseHumansHyaluronic AcidIdiopathic Pulmonary FibrosisLungMalePulmonary FibrosisRNA, MessengerRatsRats, Sprague-DawleyTissue DistributionTransforming Growth Factor beta1Up-Regulation