Conference
Interobserver Agreement for Mismatch Repair Protein Immunohistochemistry in Endometrial and Nonserous, Nonmucinous Ovarian Carcinomas
Abstract
Immunohistochemistry (IHC) for mismatch repair (MMR) proteins is an established test to identify Lynch syndrome (LS) in patients with colorectal cancer and is being increasingly used to identify LS in women with endometrial and/or nonserous ovarian cancer (OC). We assessed interobserver agreement in the interpretation of MMR-IHC on endometrial and ovarian carcinomas. The study consisted of 73 consecutive endometrial cancers (n=48) and …
Authors
Sari A; Pollett A; Eiriksson LR; Lumsden-Johanson B; Van de Laar E; Kazerouni H; Salehi A; Sur M; Lytwyn A; Ferguson SE
Volume
43
Pagination
pp. 591-600
Publisher
Wolters Kluwer
Publication Date
May 2019
DOI
10.1097/pas.0000000000001220
Conference proceedings
The American Journal of Surgical Pathology
Issue
5
ISSN
0147-5185
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Biomarkers, TumorColorectal Neoplasms, Hereditary NonpolyposisDNA Mismatch RepairDNA Repair EnzymesDNA-Binding ProteinsDecision Support TechniquesEndometrial NeoplasmsFemaleHumansImmunohistochemistryMismatch Repair Endonuclease PMS2MutL Protein Homolog 1MutS Homolog 2 ProteinObserver VariationOntarioOvarian NeoplasmsPredictive Value of TestsReproducibility of Results