Modulation of dopaminergic neurotransmission in the 6-hydroxydopamine lesioned rotational model by peptidomimetic analogues of l-prolyl-l-leucyl-glycinamide

Melanocyte stimulating hormone release inhibiting factor (MIF-1), also known as L-prolyl-L-leucyl-glycinamide (PLG), has previously been found to have the ability to modulate dopamine D2-receptor agonist binding both in the striatum and limbic regions. In the present study the 6-hydroxydopamine unilateral lesion model of apomorphine-induced rotational behaviour, in Wistar rats, was used to assess the dopaminergic modulatory activity of PLG and …