Journal article
Effects of Chronic Treatment of Haloperidol and Clozapine on Levels of G-Protein Subunits in Rat Striatum
Abstract
Chronic administration of typical neuroleptic drugs, such as haloperidol, causes the supersensitivity of brain dopamine D2 receptor in striatum and limbic regions, while the atypical neuroleptic clozapine does not. In order to understand the mechanism of their action at a molecular level, studies were carried out to assess the effects of chronic treatment of these drugs on the levels of Gproteins in the rat striatum using the Western blot …
Authors
Gupta SK; Mishra RK
Journal
Journal of Molecular Neuroscience, Vol. 3, No. 4, pp. 197–201
Publisher
Springer Nature
Publication Date
December 1992
DOI
10.1007/bf03380139
ISSN
0895-8696