Journal article
Effect of haloperidol on expression of dopamine D2 receptor mRNAs in rat brain
Abstract
Chronic administration of the neuroleptic drug haloperidol previously has been shown to increase the density of striatal dopamine D2 receptor, which is believed to be the underlying factor in neuroleptic-induced tardive dyskinesia. To search for the mechanism of receptor upregulation, the expression of the isoforms of dopamine D2 receptor mRNA in rat striatum was analyzed by Northern, solution, andin situ hybridizations in haloperidol-treated …
Authors
Srivastava LK; Morency MA; Bajwa SB; Mishra RK
Journal
Journal of Molecular Neuroscience, Vol. 2, No. 3,
Publisher
Springer Nature
Publication Date
September 1990
DOI
10.1007/bf02896840
ISSN
0895-8696