Abstract 5392: High-throughput screening of compounds for targeting system Xc(-) in human breast cancer cells

Abstract Breast cancer cells often metastasize to bone, causing severe and untreatable pain, which greatly compromises the quality of life of patients. We discovered that breast cancer cells secrete large amounts of glutamate via an amino acid antiporter Xc(-). Glutamate is an important neurotransmitter that has been associated with pain and it is also critical in bone metabolic remodeling. Excessive glutamate secreted by …