Conference
Abstract 506: H2O2 upregulates xCT in human breast cancer cells via NRF-2
Abstract
Abstract
Cancer cells adapt to high levels of oxidative stress in order to survive and proliferate, making the transcription factors involved in antioxidant defense regulation targets of interest. The transcription factor NF E2 Related Factor 2 (NRF-2) regulates cellular defense genes including those encoding intracellular redox-balancing proteins such as enzymes involved in glutathione metabolism. Glutathione in particular is …
Authors
Habib E; Linher-Melville K; Singh G
Volume
74
Pagination
pp. 506-506
Publisher
American Association for Cancer Research (AACR)
Publication Date
October 1, 2014
DOI
10.1158/1538-7445.am2014-506
Conference proceedings
Cancer Research
Issue
19_Supplement
ISSN
0008-5472