Tumour-Derived Glutamate: Linking Aberrant Cancer Cell Meta-bolism to Peripheral Sensory Pain Pathways

BACKGROUND: Chronic pain is a major symptom that develops in cancer patients, most commonly emerging during advanced stages of the disease. The nature of cancer-induced pain is complex, and the efficacy of current therapeutic interventions is restricted by the dose-limiting sideeffects that accompany common centrally targeted analgesics. METHODS: This review focuses on how up-regulated glutamate production and export by the tumour converge at …